تهیه سامانه های نانو چندسازه‌ای بر پایه پلیمرهای طبیعی و خاک رس به منظور رهایش کنترل شده داروی ضد سرطان سیس پلاتین

نوع مقاله : علمی-پژوهشی

نویسندگان

1 گروه شیمی، دانشکده علوم پایه، دانشگاه شهید مدنی آذربایجان، تبریز، ایران

2 گروه شیمی کاربردی، دانشکده شیمی، دانشگاه تبریز، تبریز، ایران

چکیده

هدف این مطالعه، توسعه سامانه رهایش کنترل شده برای داروی ضدسرطان سیس پلاتین (Cisplatin) به منظور بهبود زمان نیمه عمر و اثربخشی آن می‌باشد. سیس پلاتین در بین لایه های سیلیکاتی مونت موریلونیت سدیم (MMT) به روش بین لایه‌ای کردن محلول قرار گرفته و توسط پلیمرهای طبیعی کیتوزان (CS)، نشاسته (St) و آلژینات (Alg) احاطه می شود. به منظور بررسی اثر MMT، نانو چندسازه‌های CS/MMT/Cisplatin و St-Alg/MMT/Cisplatin با مقدارهای متفاوت MMT تهیه شدند. نانو چندسازه‌های تهیه شده با تجزیه و تحلیل­ های اسپکتروسکوپی فروسرخ تبدیل فوریه (FT-IR)، پراش پرتو ایکس (XRD) و میکروسکوپ الکترونی روبشی (SEM) شناسایی و تعیین ویژگی شدند. با آزمایش‌های برون تنی، اثر مقدار MMT و همچنین اثر pH محیط رهایش بر روی پروفیل رهایشی دارو از سامانه‌های نانو چندسازه‌ای ارزیابی شد. مطابق نتیجه‌ها، سامانه نانو چندسازه‌ای CS/MMT/Cisplatin با مقدار 50% وزنی MMT و سامانه نانو چندسازه‌ای St-Alg/MMT/Cisplatin با مقدار 30% وزنی MMT، در محیط رهایش با 4/7= pH به طور مؤثری میزان رهایش را در حد دلخواه ثابت نگه می دارد، به طوری­که زمان لازم برای رهایش 50% دارو (T50%) برای این  نانو چندسازه‌ها به ترتیب برابر با  4 روز و 14 ساعت می‌باشد. همچنین رهایش داروی سیس پلاتین در محیط به­ نسبت بازی بیش­تر از محیط اسیدی بوده و امکان مصرف خوراکی به دلیل محافظت در محیط معده وجود خواهد داشت.

کلیدواژه‌ها

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