The present study was based on an economical, eco-friendly, and efficient method for the green synthesis of silver nanoparticles in plant extract. This synthesis shows attractive characteristics such as; the use of inexpensive and available plant extracts, non-toxicity, eco-friendly biological materials, and operational simplicity. The extracts incubated with AgNO3 solution showed gradual change in color of the extracts to yellowish brown, with intensity increasing during the period of incubation. Characterization of synthesized silver nanoparticles was made by UV–Visible absorption spectroscopy, Transmission Electron Microscope (TEM), and X-Ray Diffraction (XRD) spectroscopy. The silver nanoparticles synthesized were generally found to be spherical in shape with variable size ranging from 5 to 30 nm, as evident by Transmission Electron Microscopy (TEM). The biosynthesized silver nanoparticles (AgNPs) showed good antibacterial activity against clinical strains of two bacteria (E. coli, and S. aureus).