Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECR Nashrieh Shimi va Mohandesi Shimi Iran 1022-7768 41 3 2022 11 22 Design and fabrication of a TCH/Cu complex grafted to magnetic nanoparticles and its application as a new efficient and recyclable nanocatalyst in multi-component synthesis of 2-amino-4H-chromones in aqueous medium Design and fabrication of a TCH/Cu complex grafted to magnetic nanoparticles and its application as a new efficient and recyclable nanocatalyst in multi-component synthesis of 2-amino-4H-chromones in aqueous medium 57 72 242570 FA Ali Asghar Vazini 1Faculty of Chemistry, Damghan University, Damghan, Iran Ali Reza Pourali 1Faculty of Chemistry, Damghan University, Damghan, Iran Mehdi Kalhor 2Department of Chemistry, Payame Noor University, Tehran, 19395-4697, Iran Journal Article 2020 12 22 In this project, based on previous findings, first the magnetic nanoparticles were coated with silicon dioxide particles by core-shell method and from reaction with 3-chloropropyl triethoxy silane and then with organic ligand thiocarbohydrazide (Fe₃O₄@SiO₂-TCH) was functionalized. The Cu ions were then stabilized on magnetic silicate surface. The structure of the prepared nanoparticles as a magnetic organic-metal hybrid was investigated and confirmed using FT-IR, FESEM, EDX, XRD, TGA, VSM and BET instrumental methods. Next, its catalytic activity in the synthesis of a number of 4-aryl-2-amino chromenes was investigated by the three-component condensational reaction of aldehydes, malononitrile and dimedone. The advantages of this method include cheap, safe and reusability of nanocatalyst, easy separation of heterogeneous catalyst from the reaction medium, short reaction time, high efficiency, easy and fast separation of the product and use of non-toxic water solvent, which makes this method in simplicity, be in the scope of "green chemistry". In this project, based on previous findings, first the magnetic nanoparticles were coated with silicon dioxide particles by core-shell method and from reaction with 3-chloropropyl triethoxy silane and then with organic ligand thiocarbohydrazide (Fe₃O₄@SiO₂-TCH) was functionalized. The Cu ions were then stabilized on magnetic silicate surface. The structure of the prepared nanoparticles as a magnetic organic-metal hybrid was investigated and confirmed using FT-IR, FESEM, EDX, XRD, TGA, VSM and BET instrumental methods. Next, its catalytic activity in the synthesis of a number of 4-aryl-2-amino chromenes was investigated by the three-component condensational reaction of aldehydes, malononitrile and dimedone. The advantages of this method include cheap, safe and reusability of nanocatalyst, easy separation of heterogeneous catalyst from the reaction medium, short reaction time, high efficiency, easy and fast separation of the product and use of non-toxic water solvent, which makes this method in simplicity, be in the scope of "green chemistry". https://www.nsmsi.ir/article_242570_855d557d897b3bbd1ec7b7863c3ec61b.pdf