Iranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Green Synthesis of Silver Nano Particles for Conductive Inks, Using Sonochemical TechniqueGreen Synthesis of Silver Nano Particles for Conductive Inks, Using Sonochemical Technique1914488FASahar Foroughi RadDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-413, Tehran, I.R. IRANMarzieh KhatibzadehDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-413, Tehran, I.R. IRANJournal Article20141026<em>Synthesis of silver NanoParticles (NPs) was done in aqueous solution at ambient temperature by the use of ultrasound irradiation.Silver nitrate was used as Ag precursor; gelatin and ascorbic acid were used as eco-friendly capping agent and reducing agent, respectively. Ascorbic acid was added to the 1% wt. aqueous solution of silver nitrate and gelatin slowly. This yellow solution was then sonicated while its color changed continuously to brown, indicating the formation of Ag NPs. The effect of reducing agent and stabilizing material was investigated. UV-Visible test was done for the observation of SPR peak in range of 400-450 nm, which indicates the formation of silver nanoparticles. DLS test was done for better quantitative comparison, and the results showed that the finer particles with narrower distribution can be achieved by using the optimum concentrations. Finally, by using the optimum concentrations and the proper sonication time, the silver nanoparticles were achieved having an average diameter of 7±2 nm.</em><em>Synthesis of silver NanoParticles (NPs) was done in aqueous solution at ambient temperature by the use of ultrasound irradiation.Silver nitrate was used as Ag precursor; gelatin and ascorbic acid were used as eco-friendly capping agent and reducing agent, respectively. Ascorbic acid was added to the 1% wt. aqueous solution of silver nitrate and gelatin slowly. This yellow solution was then sonicated while its color changed continuously to brown, indicating the formation of Ag NPs. The effect of reducing agent and stabilizing material was investigated. UV-Visible test was done for the observation of SPR peak in range of 400-450 nm, which indicates the formation of silver nanoparticles. DLS test was done for better quantitative comparison, and the results showed that the finer particles with narrower distribution can be achieved by using the optimum concentrations. Finally, by using the optimum concentrations and the proper sonication time, the silver nanoparticles were achieved having an average diameter of 7±2 nm.</em>https://www.nsmsi.ir/article_14488_35b291e12cecb74e7dde63bc77c4ef05.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Effect of Mn and Ni Concentration on Synthesis of Nanostructured MnNiAPSO-34 Catalyst Used in Conversion of Methanol to Light OlefinsEffect of Mn and Ni Concentration on Synthesis of Nanostructured MnNiAPSO-34 Catalyst Used in Conversion of Methanol to Light Olefins112714490FAParisa SadeghpourChemical Engineering Faculty, Sahand University of Technology, P.O. Box 51335-1996 Sahand New Town, Tabriz, I.R. IRANMohammad HaghighiReactor and Catalysis Research Center (RCRC), Sahand University of Technology,
P.O. Box 51335-1996 Sahand New Town, Tabriz, I.R. IRANJournal Article20131102<em>Nanostructured molecular sieve, SAPO-34 exhibits the best performance in the production of light olefins. Furthermore, due to the importance of MTO process, various researches have been conducted to improve SAPO-34 properties. Therefore, studying catalyst synthesis could be effective in controlling its structure and improving its properties. Using various metals like transition metals, could enhance catalyst acidity by creating new acid sites and resultantly increasing the catalyst lifetime. So, the present research is focused on the incorporation of Mn and Ni modifiers with different concentrations in synthesis of SAPO-34 zeolites to enhance the catalyst properties. MeAPSO-34s (Mn<sub>0</sub>.<sub>05</sub>Ni<sub>0.1</sub>APSO-34 and Mn<sub>0</sub>.<sub>1</sub>Ni<sub>0.05</sub>APSO-34) were synthesized by hydrothermal method using DEA as template and their catalytic properties and activities were investigated. The catalysts were characterized by XRD, FESEM, EDX, BET and FTIR techniques and catalytic performance tests were carried out toward MTO reaction. The results of XRD and FESEM for Mn<sub>0</sub>.<sub>05</sub>Ni<sub>0.1</sub>APSO-34 and Mn<sub>0</sub>.<sub>1</sub>Ni<sub>0.05</sub>APSO-34 catalysts showed a crystal size of 44.5 and 47.2 nm and particle size of 15 and 12.2 μm, respectively. The BET analysis indicated large specific surface area for the catalyst synthesized with high concentration of Mn. The catalytic performance of the synthesized catalysts in MTO reaction showed that methanol conversion of all samples were 100% in the studied range of temperatures. Moreover, Mn<sub>0.1</sub>Ni<sub>0.05</sub>APSO-34 catalyst with respect to catalyst stability and activity is much better than Mn<sub>0.05</sub>Ni<sub>0.1</sub>APSO-34. The selectivity of light olefins for this catalyst with high specific surface area was 78% after 6 h time on stream.</em><em>Nanostructured molecular sieve, SAPO-34 exhibits the best performance in the production of light olefins. Furthermore, due to the importance of MTO process, various researches have been conducted to improve SAPO-34 properties. Therefore, studying catalyst synthesis could be effective in controlling its structure and improving its properties. Using various metals like transition metals, could enhance catalyst acidity by creating new acid sites and resultantly increasing the catalyst lifetime. So, the present research is focused on the incorporation of Mn and Ni modifiers with different concentrations in synthesis of SAPO-34 zeolites to enhance the catalyst properties. MeAPSO-34s (Mn<sub>0</sub>.<sub>05</sub>Ni<sub>0.1</sub>APSO-34 and Mn<sub>0</sub>.<sub>1</sub>Ni<sub>0.05</sub>APSO-34) were synthesized by hydrothermal method using DEA as template and their catalytic properties and activities were investigated. The catalysts were characterized by XRD, FESEM, EDX, BET and FTIR techniques and catalytic performance tests were carried out toward MTO reaction. The results of XRD and FESEM for Mn<sub>0</sub>.<sub>05</sub>Ni<sub>0.1</sub>APSO-34 and Mn<sub>0</sub>.<sub>1</sub>Ni<sub>0.05</sub>APSO-34 catalysts showed a crystal size of 44.5 and 47.2 nm and particle size of 15 and 12.2 μm, respectively. The BET analysis indicated large specific surface area for the catalyst synthesized with high concentration of Mn. The catalytic performance of the synthesized catalysts in MTO reaction showed that methanol conversion of all samples were 100% in the studied range of temperatures. Moreover, Mn<sub>0.1</sub>Ni<sub>0.05</sub>APSO-34 catalyst with respect to catalyst stability and activity is much better than Mn<sub>0.05</sub>Ni<sub>0.1</sub>APSO-34. The selectivity of light olefins for this catalyst with high specific surface area was 78% after 6 h time on stream.</em>https://www.nsmsi.ir/article_14490_b0896a6fd21a2de713c18f37d34eb730.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Removal of Hexavalent Chromium by Frrite Nono ParticlesRemoval of Hexavalent Chromium by Frrite Nono Particles293714491FASara Abdolshahi NezhadPetroleum and Chemical Engineering Department, Sharif University of Technology, Tehran, I.R. IRANSeyed Mahdi BorgheiPetroleum and Chemical Engineering Department, Sharif University of Technology, Tehran, I.R. IRANMojtaba SayediPetroleum and Chemical Engineering Department, Sharif University of Technology, Tehran, I.R. IRANJournal Article20140405<em>Heavy</em><em>metals, present in many industrial wastewaters,</em><em>are</em><em> considered as </em><em>major</em><em>pollutants of environment. </em><em>Magnetic iron nanoparticles are known for their superior adsorption, ion exchange and electro-static forces characteristics. The aim of this study was to evaluate the efficiency of magnetic nanoparticles for removal of hexavalent chromium from wastewater and the parameters that influence the removal. The magnetite nanoparticles were prepared by </em><em>co-</em><em>precipitation</em><em> method</em><em> where produced Fe<sub>3</sub>O<sub>4</sub> nanoparticle’s average size was 40 nm</em><em>. </em><em>Various factors influencing the adsorption of metal ions, e.g., pH, temperature, amount of adsorbent (magnetic nanoparticles),</em><em> initial concentration of chromium</em><em>, and</em><em>contact time were investigated to optimize the operational conditions of the process and</em><em> to</em><em> detect particles of X-Ray Diffraction (XRD) pattern was used</em><em>. </em><em>Results indicated that the mechanism was strongly influenced</em><em>by solution pH, similar to many adsorption processes. At pH= 2, while initial concentration of chromium was 30 mg/L and a dose of 3.5 g/L synthesized magnetite nanoparticles was added, in 20 minutes contact time 94 % of chromium (VI) was removed. At higher pH levels of the solution, efficiency of removal declined. Final results proved that magnetite nanoparticles have high capacity for removal of chromium (VI) from solutions containing this salt, and removal efficiency for chromium(VI) is reversely related to pH. The results also showed the adsorption was decreased by increasing the initial concentrations of chromium(VI) in solutions. As expected an increase in adsorbent dosage increased the removal of chromium (VI). Equilibrium isotherms were analyzed by Langmuir</em><em>and Freundlich</em><em>adsorption models and the results proved that the behavior of chromium adsorption by Ferro-magnetic nano-particles is best expressed by Langmuir isotherm.</em><em>Heavy</em><em>metals, present in many industrial wastewaters,</em><em>are</em><em> considered as </em><em>major</em><em>pollutants of environment. </em><em>Magnetic iron nanoparticles are known for their superior adsorption, ion exchange and electro-static forces characteristics. The aim of this study was to evaluate the efficiency of magnetic nanoparticles for removal of hexavalent chromium from wastewater and the parameters that influence the removal. The magnetite nanoparticles were prepared by </em><em>co-</em><em>precipitation</em><em> method</em><em> where produced Fe<sub>3</sub>O<sub>4</sub> nanoparticle’s average size was 40 nm</em><em>. </em><em>Various factors influencing the adsorption of metal ions, e.g., pH, temperature, amount of adsorbent (magnetic nanoparticles),</em><em> initial concentration of chromium</em><em>, and</em><em>contact time were investigated to optimize the operational conditions of the process and</em><em> to</em><em> detect particles of X-Ray Diffraction (XRD) pattern was used</em><em>. </em><em>Results indicated that the mechanism was strongly influenced</em><em>by solution pH, similar to many adsorption processes. At pH= 2, while initial concentration of chromium was 30 mg/L and a dose of 3.5 g/L synthesized magnetite nanoparticles was added, in 20 minutes contact time 94 % of chromium (VI) was removed. At higher pH levels of the solution, efficiency of removal declined. Final results proved that magnetite nanoparticles have high capacity for removal of chromium (VI) from solutions containing this salt, and removal efficiency for chromium(VI) is reversely related to pH. The results also showed the adsorption was decreased by increasing the initial concentrations of chromium(VI) in solutions. As expected an increase in adsorbent dosage increased the removal of chromium (VI). Equilibrium isotherms were analyzed by Langmuir</em><em>and Freundlich</em><em>adsorption models and the results proved that the behavior of chromium adsorption by Ferro-magnetic nano-particles is best expressed by Langmuir isotherm.</em>https://www.nsmsi.ir/article_14491_b22f163e7b685a8226323a54fa449513.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Photocatatalytic Degradation of an Azo Dye by TiO2 Nanocomposites Modified with Pt, Pd and NiPhotocatatalytic Degradation of an Azo Dye by TiO2 Nanocomposites Modified with Pt, Pd and Ni394914492FAAbbas Besharati SeidaniMalek Ashtar University of Technology, Tehran, I.R. IRANMohammad Reza GholamiDepartment of Chemistry, Sharif University of Technology, Tehran, I.R. IRANJournal Article20140201<em>TiO<sub>2 </sub>nanoparticles were synthesized by sol-gel method. The modification of prepared nanoparticles was achieved with transition metals Pt, Pd and Ni. The prepared photocatalysts were characterized by XRD, BET, SEM, DRS and FT-IR Techniques. The kinetic and efficiency of photocatalytic degradation of azo dye</em><em>AB92 were investigated. The effect of some parameters such as catalyst concentration, acidity of medium, dye concentration, calcination temperature and the type of doped metal on degradation efficiency were investigated. The experimental results were indicated that the photocatalytic degradation rate is</em> <em>strongly influenced by pH and also</em> <em>it was found that the best calcination temperature is 500ºC.</em><em>TiO<sub>2 </sub>nanoparticles were synthesized by sol-gel method. The modification of prepared nanoparticles was achieved with transition metals Pt, Pd and Ni. The prepared photocatalysts were characterized by XRD, BET, SEM, DRS and FT-IR Techniques. The kinetic and efficiency of photocatalytic degradation of azo dye</em><em>AB92 were investigated. The effect of some parameters such as catalyst concentration, acidity of medium, dye concentration, calcination temperature and the type of doped metal on degradation efficiency were investigated. The experimental results were indicated that the photocatalytic degradation rate is</em> <em>strongly influenced by pH and also</em> <em>it was found that the best calcination temperature is 500ºC.</em>https://www.nsmsi.ir/article_14492_82a0bcd0a10c150f661863dbaba719f3.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Kinetic Study of Lignin Dissolution in Kraft Pulping Process of Wheat Straw by GlycerolKinetic Study of Lignin Dissolution in Kraft Pulping Process of Wheat Straw by Glycerol515714493FAElham SaberikhahFaculty of Fouman,College of Engineering, University of Tehran, P. O. Box 43515-1155, Fouman, I.R. IRANAzadeh Ebrahimian PirbazariFaculty of Fouman,College of Engineering, University of Tehran, P. O. Box 43515-1155, Fouman, I.R. IRANJamshid Mohammadi RoshandehFaculty of Caspian, College of Engineering, University of Tehran, P.O. Box 43841-119 Rezvanshahr, I.R. IRANJournal Article20131014<em>In this study, the kinetic of the lignin dissolution in paper pulping process of wheat straw by Glycerol was carried out under the reflux conditions in the presence and absent of 2% NaOH as catalyst, at 200°C and selected time 0 to 180 min. Obtained results showed with an increasing in paper pulping process time, the residual lignin in pulp, carbohydrate yield and recovery decreases in the presence and absent of catalyst. We presented rate equations versus residual lignin in paper pulp for each phase of lignin dissolution. Investigations showed the kinetic of lignin dissolution in this condition is first-order reaction and rate constants in each phase of lignin dissolution are 3×10<sup>-3</sup>, 6×10<sup>-4</sup> and 4×10<sup>-3 , </sup>1×10<sup>-3</sup> respectively.</em><em>In this study, the kinetic of the lignin dissolution in paper pulping process of wheat straw by Glycerol was carried out under the reflux conditions in the presence and absent of 2% NaOH as catalyst, at 200°C and selected time 0 to 180 min. Obtained results showed with an increasing in paper pulping process time, the residual lignin in pulp, carbohydrate yield and recovery decreases in the presence and absent of catalyst. We presented rate equations versus residual lignin in paper pulp for each phase of lignin dissolution. Investigations showed the kinetic of lignin dissolution in this condition is first-order reaction and rate constants in each phase of lignin dissolution are 3×10<sup>-3</sup>, 6×10<sup>-4</sup> and 4×10<sup>-3 , </sup>1×10<sup>-3</sup> respectively.</em>https://www.nsmsi.ir/article_14493_6464a1457bb778ad339ed2d0cda88641.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Improvement in Reactivity of Alpha Cellulose Pulp by Sono-Chemical MethodImprovement in Reactivity of Alpha Cellulose Pulp by Sono-Chemical Method596814494FAEsmaeil Rasooly GarmaroodyDepartment of Cellulose and Paper Technology, Shahid Beheshti University, Zirab Campus, Zirab, Mazandaran, I.R. IRAN0000-0002-9503-0848Elnaz Mohammadi RoudposhtiDepartment of Cellulose and Paper Technology, Shahid Beheshti University, Zirab Campus, Zirab, Mazandaran, I.R. IRANHossein Jalali TorshiziDepartment of Cellulose and Paper Technology, Shahid Beheshti University, Zirab Campus, Zirab, Mazandaran, I.R. IRANAli Akbar RazzaghiProcess Eng. of Linterpak Co., Behshahr, Mazandaran, I.R. IRANJournal Article20141221<em>Alkali absorption method was used for reactivity measurement, in mechanical (ultrasonic) and oxidation (selective and non-selective and also by H<sub>2</sub>O<sub>2</sub>) treatments of alpha cellulose fibers made from cotton Linter. Evaluation of oxidation process and mechanical treatment of fibers by measuring of viscosity, cellulose molecular weight, carboxyl groups’ substitution in methylene blue methods and also fiber alkali absorption were shown that the mechanical treatment before chemical one was led to high accessibility and reactivity of fibers. Alkali absorption depends to fiber oxidation method and mechanical treatment before that. Results show that un-selective oxidized fiber with mechanical treatment compared to untreated samples increases reactivity and carboxyl groups’ substitution 2.49% and 51.45 mmol/kg, respectively.</em><em>Alkali absorption method was used for reactivity measurement, in mechanical (ultrasonic) and oxidation (selective and non-selective and also by H<sub>2</sub>O<sub>2</sub>) treatments of alpha cellulose fibers made from cotton Linter. Evaluation of oxidation process and mechanical treatment of fibers by measuring of viscosity, cellulose molecular weight, carboxyl groups’ substitution in methylene blue methods and also fiber alkali absorption were shown that the mechanical treatment before chemical one was led to high accessibility and reactivity of fibers. Alkali absorption depends to fiber oxidation method and mechanical treatment before that. Results show that un-selective oxidized fiber with mechanical treatment compared to untreated samples increases reactivity and carboxyl groups’ substitution 2.49% and 51.45 mmol/kg, respectively.</em>https://www.nsmsi.ir/article_14494_95ea51f055a915f590626517c6ea8376.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Analysis of First and Second Thermodynamic Laws for Water Desalination System Based on Humidification-Dehumidification Process for Closed-Air Open-Water CycleAnalysis of First and Second Thermodynamic Laws for Water Desalination System Based on Humidification-Dehumidification Process for Closed-Air Open-Water Cycle697614499FATaha KhademinejadDepartment of Mechanical Engineering, Amirkabir University of Technology,
P.O. Box 15875-4413 Tehran, I.R. IRANHassan RahimzadehDepartment of Mechanical Engineering, Amirkabir University of Technology,
P.O. Box 15875-4413 Tehran, I.R. IRANJournal Article20140405<em>The humidification-dehumidification desalination system is a carrier-gas-based thermal desalination technique which is ideal for small-scale water production purposes. This technique has attracted many attentions in previous years due to low fossil energy demand and its low integration costs. In this paper, the water desalination system based on humidification-dehumidification process in closed-air open-water cycle is investigated thermodynamically by the commercial software EES. Furthermore, the effects of the governing parameters such as humidifier and dehumidifier effectiveness ( and ), temperature of the inlet water into the humidifier and dehumidifier (</em><em> </em><em>and </em><em>) and mass rate ratio (</em><em>) are investigated to maximize the performance of the system which is presented by Gained Output Ratio (GOR) and minimize the non-dimension entropy generation rate (</em><em>). Form thermodynamic analysis of the system we can conclude that the efficiency of the whole system is more affected by efficiency of the dehumidifier rather than the efficiency of the humidifier. Moreover, in low mass rate ratio,GOR increase for lower inlet water temperatures of dehumidifier. On the other hand, in high mass rate ratio, higher temperatures of inlet dehumidifier water will lead to higher performance (GOR) of the system.</em><em>The humidification-dehumidification desalination system is a carrier-gas-based thermal desalination technique which is ideal for small-scale water production purposes. This technique has attracted many attentions in previous years due to low fossil energy demand and its low integration costs. In this paper, the water desalination system based on humidification-dehumidification process in closed-air open-water cycle is investigated thermodynamically by the commercial software EES. Furthermore, the effects of the governing parameters such as humidifier and dehumidifier effectiveness ( and ), temperature of the inlet water into the humidifier and dehumidifier (</em><em> </em><em>and </em><em>) and mass rate ratio (</em><em>) are investigated to maximize the performance of the system which is presented by Gained Output Ratio (GOR) and minimize the non-dimension entropy generation rate (</em><em>). Form thermodynamic analysis of the system we can conclude that the efficiency of the whole system is more affected by efficiency of the dehumidifier rather than the efficiency of the humidifier. Moreover, in low mass rate ratio,GOR increase for lower inlet water temperatures of dehumidifier. On the other hand, in high mass rate ratio, higher temperatures of inlet dehumidifier water will lead to higher performance (GOR) of the system.</em>https://www.nsmsi.ir/article_14499_db9434d7223e019302a0d7c80e5047aa.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Thermal and Hydraulic Analysis of the Wavy-Fins-Plate Compact Heat ExchangersThermal and Hydraulic Analysis of the Wavy-Fins-Plate Compact Heat Exchangers7710414502FAHanieh Ghanbar Kharghani NejadDepartment of Chemical Engineering, Faculty of Engineering, Islamic Azad University, Science and Research Branch, Tehran, I.R. IRANMohammad Reza Jafari NasrResearch Institute of Petroleum Industry (RIPI), Tehran, I.R. IRANJournal Article20141108<em>Thermo-hydraulic analysis of compact heat exchangers is strongly depended on the performance of heat transfer surfaces. This is evaluated by Colburn and Fanning friction factors versus Reynolds number. In this paper, CFD analysis is carried on with 18 different type of wavy fins geometries. The effects of the four geometrical factors of fin; height, fin spacing, wave amplitude, wavelength over a wide range of Reynolds number are investigated. Then a parametric study for two enhanced designs C-shaped and S-shaped sinusoidal wavy offset-strip fins is conducted. Those four geometrical factors described the wavy channel and combined and related by the parameters α, β and γ which represent the dimensionless geometrical parameters. The numerical computations are performed by solving a steady, three dimensional Navier-Stokes equation and energy equation using Ansys Fluent 15.0 software program. Air is considered as working fluid. The computational results have an adequate accuracy when compared to experimental data. The CFD simulation results reveal that the geometrical parameters of wavy fins have significant effects on the j and f factors as a function of Reynolds number.</em><em>Thermo-hydraulic analysis of compact heat exchangers is strongly depended on the performance of heat transfer surfaces. This is evaluated by Colburn and Fanning friction factors versus Reynolds number. In this paper, CFD analysis is carried on with 18 different type of wavy fins geometries. The effects of the four geometrical factors of fin; height, fin spacing, wave amplitude, wavelength over a wide range of Reynolds number are investigated. Then a parametric study for two enhanced designs C-shaped and S-shaped sinusoidal wavy offset-strip fins is conducted. Those four geometrical factors described the wavy channel and combined and related by the parameters α, β and γ which represent the dimensionless geometrical parameters. The numerical computations are performed by solving a steady, three dimensional Navier-Stokes equation and energy equation using Ansys Fluent 15.0 software program. Air is considered as working fluid. The computational results have an adequate accuracy when compared to experimental data. The CFD simulation results reveal that the geometrical parameters of wavy fins have significant effects on the j and f factors as a function of Reynolds number.</em>https://www.nsmsi.ir/article_14502_5f1000946c755a5ea177143865f36a42.pdfIranian Institute of Research and Development in Chemical Industries (IRDCI)-ACECRNashrieh Shimi va Mohandesi Shimi Iran1022-776834120150522Design and Manufacture of a Disposable Shaken Bioreactor in Pilot ScaleDesign and Manufacture of a Disposable Shaken Bioreactor in Pilot Scale10511114503FAHotan GoldoostSchool of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRANGhasem AmoabediniSchool of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRANHamid RashediSchool of Chemical Engineering, College of Engineering, University of Tehran, Tehran, I.R. IRANEmad ImenipourInstitute of Millibioreactor and Screening Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, I.R. IRANEmad ImenipourInstitute of Millibioreactor and Screening Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, I.R. IRANMahdi Pesaran HajiabbasInstitute of Millibioreactor and Screening Engineering, Research Center for New Technologies in Life Science Engineering, University of Tehran, Tehran, I.R. IRANJournal Article20111016<em>In this paper, design and manufacturing of a pilot scale shaken disposable bioreactor was studied. The very simple, versatile and widely used shaken technology was combined with the cylindrical disposable reactors to make it an ideal choice for cultivation of plant, animal and insect cell cultures for pilot-scale production. To study scale up parameters, cylindrical millibioreactors of 500 mL volume as lab-scale models and disposable bioreactors up to 50 L volume as the main bioreactors were thoroughly characterized in terms of important engineering parameters such as mixing, power consumption, and oxygen transfer rate. To evaluate these bioreactors, some case studies were conducted. Tests were done using the Sulfite System which is a promising method based on oxidation of SO<sub>3 </sub>to SO<sub>4</sub>. Effect of RPM, filling volume, aeration and power consumption were studied on bioreactor operation and scale up parameters discussed based on the presented results. The best performance obtained at 250 RPM with 20% filling volume. Power consumption was highly dependent on mixing and increasing the RPM from 200 to 250 and subsequent 13% reduction in mixing time led to 50% increase in power consumption. Hence,the choice of optimum economic condition will be project dependent. As the final verification, OTR<sub>max</sub> values were calculated. The maximum and minimum values were 0.028 and 0.008 mol/L/hr (at 250 and 100 RPM) respectively. The minimum OTR<sub>max</sub> obtained in this large shaking bioreactor is twice as the maximum oxygen demand of plant, animal and insect cells reported in references and hence these cells can be easily cultivated at relatively “mild” operating conditions.</em><em>In this paper, design and manufacturing of a pilot scale shaken disposable bioreactor was studied. The very simple, versatile and widely used shaken technology was combined with the cylindrical disposable reactors to make it an ideal choice for cultivation of plant, animal and insect cell cultures for pilot-scale production. To study scale up parameters, cylindrical millibioreactors of 500 mL volume as lab-scale models and disposable bioreactors up to 50 L volume as the main bioreactors were thoroughly characterized in terms of important engineering parameters such as mixing, power consumption, and oxygen transfer rate. To evaluate these bioreactors, some case studies were conducted. Tests were done using the Sulfite System which is a promising method based on oxidation of SO<sub>3 </sub>to SO<sub>4</sub>. Effect of RPM, filling volume, aeration and power consumption were studied on bioreactor operation and scale up parameters discussed based on the presented results. The best performance obtained at 250 RPM with 20% filling volume. Power consumption was highly dependent on mixing and increasing the RPM from 200 to 250 and subsequent 13% reduction in mixing time led to 50% increase in power consumption. Hence,the choice of optimum economic condition will be project dependent. As the final verification, OTR<sub>max</sub> values were calculated. The maximum and minimum values were 0.028 and 0.008 mol/L/hr (at 250 and 100 RPM) respectively. The minimum OTR<sub>max</sub> obtained in this large shaking bioreactor is twice as the maximum oxygen demand of plant, animal and insect cells reported in references and hence these cells can be easily cultivated at relatively “mild” operating conditions.</em>https://www.nsmsi.ir/article_14503_9f6a86d46945815384cb619c3ae7a04d.pdf