Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

Experimental Study of Chitosan Coating Effect on Reducing Aggregation of Multiwall Carbon Nanotubes as a Career for Delivery of Anticancer “Quercetin” Drug

Document Type : Research Article

Authors
Masoomeh Nabitir 1
Seyed Foad Aghamiri 2
Mohammad Reza Talaie 2
1 Department of Chemical Engineering, Faculty of Engineering, University of Isfahan, Isfahan,I.R. IRAN
2 Department of Chemical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, I.R. IRAN
Abstract
Carbon nanotubes (CNTs) are used for many applications in the biomedical field such as drug delivery. Low biocompatibility and a high tendency for aggregation are the most problem of CNTs in drug delivery application. In this article effect of coating natural biocompatible polymer chitosan on reducing aggregation of multiwall carbon nanotubes as a carrier for delivery of anticancer “Quercetin” drug is studied. Synthesize of oxidized multiwall carbon nanotubes (OX-MWNT) and its modification with chitosan (CS-OXMWNT) was characterized by Fourier Transform InfraRed Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). Dispersion of MWNT, OX-MWNT, CS-OXMWNT, and QC-CSOXMWNT in aqueous solution has been monitored by UV–Vis spectroscopy and turbidimeter analyze. According to UV–vis spectroscopy and turbidimeter analyses dispersion of CS-OXMWNT higher than MWNT, and decreases by drug loading. The turbidity of CS-OXMWNT and MWNT were 17.29 and 11.12 NTU respectively. The dispersion solutions are approximately stable for 24h.
Keywords
Aggregation
Carbon Nanotube
Drug Delivery
Quercetin
Chitosan

Subjects

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