Investigation of Physicochemical Properties Nanophytosome obtained from of Polyphenolic Enrich fraction of Satureja khuzistanica by Freeze-drying

Fathi, Faezeh; Nejad Ebrahimi, Samad

Investigation of Physicochemical Properties Nanophytosome obtained from of Polyphenolic Enrich fraction of Satureja khuzistanica by Freeze-drying

Document Type : Research Article

Authors

Faezeh Fathi

Samad Nejad Ebrahimi

1Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Iran

Abstract

Phytosome technique is a new method for encapsulating natural compounds to increase bioavailability and absorption in the biological environment. Phytosome provides maximum adsorption conditions in target cells due to the use of phospholipids as coatings. This project aims to present a suitable method for encapsulating the polyphenolic enrich extract of Satureja khuzistanica in the phytosome structure by thin-film hydration following ultrasonication and freeze-drying. Phytosome structures were analyzed by particle size, morphology, and time-release mechanism. The results showed the phytosome particle size in the dimensions of 82.2 nm was stable for six months. The release of phytomose structure properly adjusted on Korsmeyer mechanism and release drug transport occurs by diffusion following Fick law (case-I transport).

Keywords

Polyphenols

Satureja khuzitanica

Phytosome

Freeze dryer

release

Subjects

[1] Shahabi J., Akbarzadeh A., Heydari Nasab A., Arjmand M., Doxorubicin Loaded Liposomal Nanoparticles Containing Quantum Dot for Treatment of Breast Cancer, Iran. J. Chem. Chem. Eng. (IJCCE), 38(5): 45–53 (2019).

[2] Burey P., Bhandari B. R., Howes T., Gidley M. J., Hydrocolloid Gel Particles: Formation, Characterization, and Application, Crit. Rev. Food Sci. Nutr, 48(5): 361–377 (2008).

[3] Nedovic V., Kalusevic A., Manojlovic V., Levic S., Bugarski B., An Overview of Encapsulation Technologies for Food Applications, Procedia Food Sc., 1: 1806–1815 (2011).

[4] Dewan N., Dasgupta D., Pandit S., Ahmed P., Review on- Herbosomes, A New Arena for Drug Delivery, J. Pharmacogn. Phytochem, 5(4): 104–108 (2016).

[5] Bhingardeve D., Patil S., Patil R., Patil S., Phytosome- Valuable Phyto-Phospholipid Carriers, J. Curr. Phrama Res, 5(1): 7842 (2014).

[6] Duarte, J., Pérez-Vizcaíno, F., Zarzuelo A., Jiménez J., Tamargo J., Vasodilator Effects of Quercetin in Isolated Rat Vascular Smooth Muscle, Eur. J. Pharmacol, 239(1993): 1–7 (2000).

[7] Patel J., Patel R., Khambholja K., Patel N., An Overview of Phytosomes as an Advanced Herbal Drug Delivery System, Asian J. Pharm. Sci, 4(6): 363–371 (2009).

[8] Kidd P.M., Bioavailability and Activity of PHytosome Complexes from Botanical Polyphenols: The Silymarin, Curcumin, Green Tea, and Grape Seed Extracts, Altern. Med. Rev, 14(3): 226–46 (2009)

[9] Parris K., Kathleen Head, ND., A Review of the Bioavailability and Clinical Efficacy of Milk Thistle Phytosome: A Silybin-Phosphatidylcholine Complex, Alternative Medicine Review, 10(3): 193-203 (2005).

[10] A. Gandhi, A. Dutta, A. Pal, P. Bakshi, “Recent Trends of PHytosomes for Delivering Herbal Extract with Improved Bioavailability, J. Pharmacogn. Phytochem, 1(4): 6–14 (2012).

[11] Young-Hee C., Shin Dong-Suck S., Optimization of Emulsification and Spray Drying Process for the Microencapsulation of Flavor Compounds, Korean J. Food Sci, 32(1): 132–139 (2000).

[12] Mazarei Z., Rafati H., Nanoemulsiﬁcation of Satureja Khuzestanica Essential Oil and Pure Carvacrol; Comparison of Physicochemical Properties and Antimicrobial Activity Against Food Pathogens, Lwt, 100: 328–334 (2019).

[13] Hasheminya S. M., Mokarram R. R., Ghanbarzadeh B., Hamishekar H., Kafil H. S., Dehghannya J., Influence of Simultaneous Application of Copper Oxide Nanoparticles and Satureja Khuzestanica Essential Oil on Properties of Kefiran–Carboxymethyl Cellulose Films, Polym. Test, 73: 377–388 (2019).

[14] Jafari F., Ghavidel F., Zarshenas M. M., A Critical Overview on the Pharmacological and Clinical Aspects of Popular Satureja Species, JAMS J. Acupunct. Meridian Stud, 9(3): 118–127 (2016).

[15] Siavash Saei-Dehkordi S., Fallah A. A., Heidari-Nasirabadi M., Moradi M., Chemical Composition, Antioxidative Capacity and Interactive Antimicrobial Potency of Satureja Khuzestanica Jamzad Essential Oil and Antimicrobial Agents Against Selected Food-Related Microorganisms, Int. J. Food Sci. Technol, 47(8): 1579–1585 (2012).

[16] Giannouli E., Athanasopoulos D., Panagopoulos G., Tsiara S., Karageorgiou C. E., Paraneoplastic Syndromes Associated with Merkel Cell Carcinoma: A Case Series of Eight Patients Highlighting Different Clinical Manifestations, J. Am. Acad. Dermato., 75(3): 541–547 (2016).

[17] Jung-won M., Dong-jin P., Kwang H E E S., Ki-hong Y., Hae-ryong, P., Young-soo P., Mu-gil K., Jung-min L., Chang-jin K., “Large-Scale Fermentation for the Production of Teicoplanin from a Mutant of Actinoplanes Teichomyceticus, J. Microbiol. Biotechnol, 15(4): 787–791 (2005).

[18] Brochure P. L., “Mitsubishi-DIAION-Resin-Lenntech”, Mitsubishi Chem, (2013).

[19] Fei Yu., Yang Li., Qin C., Yuan H., Huiyun W., Liu Y., Shangjing G., Zhaohui M., Jinghao C., Mei X., Xiao D C., Monodisperse Microparticles Loaded with the self-Assembled Berberine-Phospholipid Complex-Based Phytosomes for Improving Oral Bioavailability and Enhancing Hypoglycemic Efficiency, Eur. J. Pharm. Biopharm, 103: 136–148 (2016).

[20] Anwar E., Farhana N., Formulation and Evaluation of Phytosome-Loaded Maltodextrin-Gum Arabic Microsphere System for Delivery of Camellia Sinensis Extract, J. Young Pharma, 10(2s): 56-S62 (2018).

[21] Permanadewi I., Kumoro A. C., Wardhani D. H., Aryanti N., Modelling of Controlled Drug Release in Gastrointestinal Tract Simulation, J. Phys. Conf. Ser, 1295: 1 (2019).

[22] Siepmann J., Siegel R. A., Rathbone M. J., Fundamentals and Applications of Controlled Release Drug Delivery, Adv. Deliv. Sci. 15(2): 19-43 (2012).

[23] Hadian J., Mirjalili M. H., Kanani M. R., Salehnia A., Ganjipoor P., Phytochemical and Morphological Characterization of Satureja Khuzistanica J Amzad Populations from Iran, Chem. Biodivers, 8(5): 902–915 (2011).

[24] Davoodi M., Rustaiyan A., Ebrahimi S. N., Monoterpene Flavonoid from Aerial Parts Of Satureja Khuzistanica, Rec. Nat. Prod, 12( 2): 175–178, (2017).

[25] Fatemi F., Abdollahi M. R., Mirzaie-asl A., Dastan D., Garagounis C., Papadopoulou K., “Identification and Expression Profiling of Rosmarinic Acid Biosynthetic Genes from Satureja Khuzistanica Under Carbon Nanotubes and Methyl Jasmonate Elicitation,” Plant Cell. Tissue Organ Cult, 136(3): 561–573, (2019).

[26] Mazarei Z., Rafati H., Nanoemulsification of Satureja khuzestanica Essential Oil and Pure Carvacrol; Comparison of Physicochemical Properties and Antimicrobial Activity Against Food Pathogens, Lwt, 100: 328–334, (2019).

[27] Maryana W., Rachmawati H., Mudhakir D., Formation of Phytosome Containing Silymarin Using Thin Layer-Hydration Technique Aimed for Oral Delivery, Mater. Today Proc, 3(3): 855–866 (2016).

[28] Antonella R., Jacopo A. V., Gianni B., Shu H., Beatrice F., Giulia V., Marisa V., Ezio B., Luca G., Roberto E., Stefano T., Quercetin Phytosome^® in Triathlon Athletes: A Pilot Registry Study, Minerva Med, 109(4): 285–289 (2018).

[29] Abd El-Fattah A. I., Fathy M. M., Ali Z. Y., El-Garawany A. E.-R. A., Mohamed E. K., Enhanced Therapeutic Benefit of Quercetin-Loaded Phytosome Nanoparticles in Ovariectomized Rats, Chem. Biol. Interact, 271: 30–38 (2017).

[30] Giada M., Stefano T., Ivan P., Luca G., Roberta C., Samuele B., Roberto E., Soothing and Anti-Itch Effect of Quercetin Phytosome in Human Subjects: A Single-Blind Study, Clin. Cosmet. Investig. Dermatol, 26(9): 55-62 (2016).

[31] Wojcik-Pastuszka D., Krzak J., Macikowski B., Berkowski R., Osiński B., Musiał W., Evaluation of the Release Kinetics of a Pharmacologically Active Substance from Model Intra-Articular Implants Replacing the Cruciate Ligaments of the Knee, Materials (Basel), 12(8): 1-13 (2019).