Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

One-Pot Synthesis of Oxazoles by the Reaction of Carboxylic Acids, Benzoin, and Ammonium Acetate

Document Type : Research Article

Authors
Najmeh Nowrouzi 1
Soghra Farahi 2
Maryam Irajzadeh 1
1 Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRAN
2 Department of Chemistry, Faculty of Sciences, Behbahan Khatam Alanbia University of Technology, Behbahan, I.R. IRAN
Abstract
A green protocol for the preparation of 4,5-diphenyl-2(R)-oxazoles from the reaction of benzoin, carboxylic acids, and ammonium acetate is described. This process is accomplished without the use of any organic solvent or catalyst. By this method, aromatic acids carrying electron-withdrawing groups reacted faster with higher yields. However, the reaction has generality for those with electron-donating groups and ortho-substituted ones. Even aliphatic carboxylic acids also provided the corresponding oxazoles in appropriate yields. Extraction of the product is simply achieved by the addition of water to the reaction mixture.
Keywords
Oxazole
Carboxylic acid
Benzoin
Ammonium Acetate
Solvent free

Subjects

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