سنتز تک ظرف اکسازول ها به روش واکنش اسیدهای کربوکسیلیک، بنزوئین و آمونیوم استات

نوع مقاله : علمی-پژوهشی

نویسندگان

1 گروه شیمی، دانشکده علوم پایه، دانشگاه خلیج فارس بوشهر، بوشهر ، ایران

2 گروه شیمی، دانشکده علوم پایه، دانشگاه صنعتی خاتم الانبیاء (ص) بهبهان، بهبهان ، ایران

چکیده

یک روش مؤثر و سازگار با محیط زیست برای تهیه 5،4-دی فنیل-2(R)-اکسازول­ ها با واکنش بنزوئین، اسیدهای کربوکسیلیک و آمونیوم استات توصیف می ­شود. این فرایند بدون استفاده از حلال و کاتالیست انجام شد. در این روش، اسیدهای آروماتیکی که حامل گروه کشنده الکترون هستند سریع­تر واکنش داده و فراورده‌ی مربوطه را با بازده بیش­تری تولید کردند. این واکنش برای آن دسته از اسیدهایی که حامل گروه دهنده الکترون هستند یا در موقعیت اورتو استخلاف دارند، نیز عمومیت داشت. حتی اسیدهای کربوکسیلیک آلیفاتیک هم اکسازول­ های مربوطه را با بازده مناسبی فراهم آوردند. با توجه به این­که فراورده‌های واکنش جامد بودند، استخراج فراورده‌ها به سادگی به­ وسیله افزودن آب به مخلوط واکنش و صاف کردن انجام شد.

کلیدواژه‌ها

موضوعات

مراجع

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