مطالعه برهمکنش کمپلکس های نیکل (II) دارای لیگاندهای آروماتیک مسطح با DNA غده تیموس

نوع مقاله : علمی-پژوهشی

نویسندگان

1 زاهدان، دانشگاه آزاد اسلامی، واحد علوم و تحقیقات سیستان و بلوچستان

2 تهران، دانشگاه تهران، مرکز تحقیقات بیوشیمی و بیوفیزیک

3 زاهدان، دانشگاه سیستان و بلوچستان، دانشکده علوم، گروه شیمی

4 کرج، پژوهشگاه مواد و انرژی، پژوهشکده فناوری نانو و مواد پیشرفته

5 تهران، دانشگاه خوارزمی، گروه علوم زیستی

چکیده

سه کمپلکس نیکل با فرمول های 2)3](NO2[Ni(en)، 2)3](NO2[Ni(phen)، 2)3](NO2[Ni(bpy)(به ترتیب a، b و c) که در آنها =en اتیلن دی آمین، =bpy 2 و 2- بی پیریدین و =phen 1و 10 فنانترولین است تهیه شد. ساختار این کمپلکس ها توسط روش های طیف سنجی فرا بنفش، فروسرخ، رزونانس مغناطیسی هسته و روش‌های هدایت سنجی و تجزیه عنصری شناسایی شد. برهمکنش این سه کمپلکس محلول در آب با DNA غده تیموس به روش های جذب الکترونیکی، فلوئورسانس و ژل فیلتراسیون مطالعه شد. این کمپلکس ها می‌ توانند DNAرا در غلظت های بسیار کم، غیرطبیعی کنند. برهمکنش بین کمپلکس‌های bو cکه دارای لیگاندهای آروماتیک و مسطح هستند، شاید از نوع اینترکیلیشن باشد. همچنین، کمپلکس c می‌تواند DNAرا به دو قطعه برش داده و با هر دو برهمکنش داشته باشد.

کلیدواژه‌ها

موضوعات


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