نشریه شیمی و مهندسی شیمی ایران

نشریه شیمی و مهندسی شیمی ایران

نانو حامل های پایه کیتوسان برای رهایش داروی ضد سرطان کورکومین: مطالعه مروری

نوع مقاله : مروری

نویسندگان
1 دانشکده شیمی، دانشگاه صنعتی امیرکبیر ، تهران، ایران
2 گروه مهندسی پلیمر، دانشکده فنی و مهندسی، دانشگاه آزاد اسلامی واحد تهران جنوب، تهران، ایران
3 گروه شیمی، واحد شهر قدس، دانشگاه آزاد اسلامی، تهران، ایران
چکیده
داروی کورکومین یک پلی فنول زرد رنگ است که عمدتا از گیاه کورکوما لانگا و همچنین از چندین عضو دیگر خانواده زنجبیل، استخراج می­ شود. برای غلبه بر حلالیت آبی و فراهمی زیستی ضعیف داروی کورکومین، تأکید بر ویژگی‌های عملکردی آن و گسترش کاربردهای آن در صنایع دارویی به طور گسترده،  بسیاری از سیستم‌های نانومقیاس برای بارگذاری و رهایش دارو استفاده شده‌اند. در طی چندین دهه، کیتوسان به عنوان یک زیست پلیمر طبیعی به طور گسترده­ای مورد استفاده قرار گرفته است. به دلیل ماهیت پلی کاتیونی، زیست تخریب پذیری، زیست سازگاری، غیر سمی بودن و غیر آلرژی زا بودن آن مورد مطالعه قرار گرفت. اصلاح کیتوسان برای کاربردهای گوناگون می­ تواند به راحتی با توجه به گروه ­های فعال فراوان (NH2 و OH) در زنجیره اصلی به دست آید. رهایش کنترل شده دارو به منظور حفظ غلظت درمانی بهینه دارو در خون است که باعث افزایش ماندگاری و مدت فعالیت داروهای با نیمه عمر کوتاه  می­ شود. رهایش کنترل شده دارو موجب می­ شود که سرعت رهایش دارو برای داروهای با رهایش طولانی،  مدت قابل پیش بینی و تکرار پذیر داشته باشد.  بنابراین  توسعه سیستم­ های کلوئیدی برای کپسوله ­سازی ورهایش کورکومین یک استراتژی امیدوارکننده برای غلبه بر محدودیت­ های رهایش دارو  می­ باشد. در این پژوهش، به بررسی نانوحامل ­های بر پایه کیتوسان و خواص فیزیکی و شیمیایی، مانند بار سطحی، ریخت­ شناسی، نیروی محرکه کپسولاسیون، و مشخصات رهایش، پرداخته می ­شود که این ویژگی‌ها عملکرد نانوحامل‌های بر پایه کیتوسان را برای کاربردهای دارویی تعیین می‌کنند.
کلیدواژه‌ها

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