نشریه شیمی و مهندسی شیمی ایران

نشریه شیمی و مهندسی شیمی ایران

طراحی و ترکیب نانوکامپوزیت های نوین کارآمد Fe3O4@MCM-41/HAP/APTES و CMC/MMT/HAP برای دارورسانی رهایش کنترل شده: تحویل هدفمند تری پاراتاید در مهندسی بافت استخوان

نوع مقاله : علمی-پژوهشی

نویسندگان
حمیدرضا حسینی 1
مجید عبدوس 2
مصطفی گلشکن 3
پدارم طهرانی 1
1 گروه مهندسی پزشکی، واحد تهران مرکزی، دانشگاه آزاد اسلامی، تهران، ایران
2 گروه شیمی، دانشگاه صنعتی امیرکبیر، تهران، ایران
3 مرکز تحقیقات بیوتکنولوژی پزشکی، دانشگاه علوم پزشکی گیلان، رشت، ایران
چکیده
رویکرد تحویل دارو در مهندسی بافت استخوان به دلیل آناتومی پیچیده استخوان و نیز محدودیت­ های دارورسانی با چالش­ هایی روبرو است. در پاسخ، نانوکامپوزیت های جدید و کارآمد پاسخگو بهpH ، شامل نانوذرات مگنتیت(Fe3O4)، ترکیب موبیل ماده شماره 41(MCM-41)، هیدروکسی آپاتیت(HAP)، 3-آمینو پروپیل (تری اتوکسی سیلان(APTES)، کربوکسی متیل سلولوز(CMC) و مونت موریلونیت(MMT)، (Fe3O4@MCM-41/HAP/APTES)]و هیدروژل[(CMC/MMT/HAP)  برای تحویل دقیق تری پاراتید (PTH (1-34 با هدف افزایش حلالیت، پایداری دارو و رهایش کنترل شده توسعه یافته است که جهت کاهش عوارض جانبی، نگرانی‌های ایمنی و ناراحتی ناشی از تزریق‌های مکرر بالقوه ­اند. نانوکامپوزیت‌ها از طریق فنون تحلیلی مختلف، از جمله پراش پرتو ایکس (XRD)، طیف‌سنجی فروسرخ تبدیل فوریه (FT-IR)، تجزیه و تحلیل پتانسیل زتا، پراکندگی دینامیک نور (DLS) و میکروسکوپ الکترونی روبشی گسیلی میدانی(FE-SEM)، مورد بررسی قرار گرفتند. قطر بلوری متوسط نانوکامپوزیت­ ها به ترتیب  4 ± 27.6 و  1.4 ± 29.2 نانومتر از رابطه شرر محاسبه شد و اندازه قطر هیدرودینامیکی به ترتیب 8.3 ± 417.023 و 3.8 ± 193.48 نانومتر و بار سطحی پایداربه ترتیب31- و40- میلی ولت را نشان دادند. علاوه بر این، بازده بارگذاری و گیر افتادن به ترتیب 37% و 90% برای نانوکامپوزیت اول و  38% و 82%  برای نانو کامپوزیت دوم تعیین شد. آزمایش‌های انتشار دارو با استفاده از روش دیالیز همراه با تحلیل کروماتوگرافی مایع با کارایی بالا (HPLC)، الگوی رهش پایدار را نشان دادند. با کاهش pH  از 7.4 به 5.6، افزایش متناظر در انتشار دارو وجود داشت. نتایج مطالعه ‌سینتیک‌ رهایش‌ دارو ‌از ‌مدل ‌هیگوچی ‌پیروی کرد‌‌‌ که‌ کاملا با ویژگی‌های هدف آزادسازی ‌نانوحامل‌‌ها و‌داروی‌ تری‌پاراتاید‌ مطابقت ‌داشت و حفظ یکپارچگی نانو حامل را تایید کرد. نتایج تست سمیت سلولی طی 24 ساعت روی رده سلولی NIH3T3  نه تنها هیچ سمیتی را نشان نداد بلکه اثر تکثیر و تمایز سلولی را ثبت کرد که این مشاهدات در مورد رده سلولی Saos-2 کنترل و محدود شد.  بر اساس این یافته­ ها، نانوکامپوزیت­ های طراحی و ساخته شده با بیشترین تاثیر اجزا در بازسازی بافت استخوان، به عنوان یک سیستم دارورسانی، رویکردی بسیار کارآمد و زیست سازگار را برای افزایش اثربخشی درمانی ارائه و در نتیجه بر محدودیت‌های مرتبط با تحویل دارو غلبه می‌کنند.
کلیدواژه‌ها
نانوحامل های دارورسانی
هیدروکسی آپاتیت
نانوذرات مگنتیت
مونت موریلونیت
کربوکسی متیل سلولز
تری پاراتاید

موضوعات

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