یک حسگر الکتروشیمیایی بر پایه ی پلیمر قالب ملکولی نوین برای تعیین فنیل افرین هیدروکلرید درنمونه دارویی

نوع مقاله : علمی-پژوهشی

نویسندگان

گروه شیمی، دانشگاه پیام نور، تهران، ایران

چکیده

در این پژوهش، یک پلیمر قالب گیری شده با ملکول برای اندازه گیری فنیل افرین هیدروکلرید ارایه شده است. پلیمر قالب گیری شده ملکولی (MIP) به­وسیله الکتروپلیمریزاسون و با به­کار بردن 1و 4 ـ فنیلن دی آمین (PE) به­عنوان مونومر و فنیل افرین هیدروکلرید(PHE) به­ عنوان الگو آماده شد. ارزیابی پاسخ حسگر به­وسیله مقایسه ی پاسخ الکتروشیمایی پلیمر قالب ملکولی و پلیمر بدون قالب ملکولی (NIP)  در محلول پتاسیم فروسانید 0/2 میلی مولار محتوی سدیم سولفات 2/0 مولار، که به ­عنوان محلول حسگر می باشد، انجام شد. اندازه گیری ها در بازه­ ی 6/0- تا 8/0+ ولت و با سرعت روبش 50 میلی ولت بر ثانیه انجام گرفت. تعدادی از پارامترها بر پاسخ پروب بهینه شدند و منحنی برازش رسم شد. فنیل افرین هیدروکلرید در بازه­ی غلظتی µM 110-5  خطی بود. حد تشخیص µM 9/0 بود. این روش برای تعیین فنیل افرین هیدروکلرید در نمونه داروی کلداکس استفاده شد.

کلیدواژه‌ها

موضوعات

مراجع

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