Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

Numerical Modeling of the Organic Materials Micronizer and Prediction of the Characterizations of Particles Molten During the Micronization Process

Document Type : Research Article

Authors
Parviz Ahmadi Aval 1
Fathollah Pourfayaz 2
Zahra Sheibani 1
Morteza Jafari Kojur 1
1 Chemical Additive Design Research Group, University of Tehran Branch, ACECR, Tehran, I.R. IRAN
2 Department of New Energy and Environment, Faculty of Modern Science and Technology, University of Tehran, Tehran, I.R. IRAN
Abstract
The application of atmospheric spraying micronized powder device is a new method to dry and powder thermosensitive solutions. The inlet material could be pure ort with dispersed particles or a solution of different materials. In this research, stearic acid was used as the molten organic compound for producing powder, and calculations were performed to design a device with a production capacity of up to 500 kg/h and powder diameters of up to 300 µm. In order to better understanding the heat and momentum transfer phenomenon and powders freezing process inside the chamber, powder’s temperature, velocity, and phase profiles were calculated. Based on mathematical model results, the inlet cooling air temperature has a significant impact on powders diameter and increasing that temperature from 5 oC to 30 oC could duplicate the diameterof the produced powders. Chamber wall temperature is another important parameter and using
a cooling system has a significant effect on powders freezing time and device required height.
Keywords
Spraying micronized powder device
Mathematical modeling
Stearic acid
Convective heat transfer coefficient
Temperature and velocity profile

Subjects

[1] Chen T., Zhang M., Bhandari B., Yang Z., Micronisation and Nanosizing of particles for an Enhanced Quality of Food: a Review, Crit. Rev. Food Sci. Nutr., 58: 993-1001 (2018).
[2] قمرطالع، علی؛ صبوری، رحمت اله؛ صباغی، صمد؛ شبیه‌سازی اثر نانو و میکرو ذره‌ها بر میزان افت فشار درون خطوط انتقال نفت، نشریه شیمی و مهندسی شیمی ایران، (2)6: 193 تا 200 (1396).
[3] Ganguly A., Nail S.L., Alexeenko A., Experimental Determination of the Key Heat Transfer Mechanisms in Pharmaceutical Freeze‐Drying, J. Pharm. Sci., 102: 1610-1625 (2013).
[4] Wanning S., Süverkrüp R., Lamprecht A., Pharmaceutical Spray Freeze Drying, Int. J. Pharm., 488: 136-153 (2015).
[5] Patel S.M., Pikal M.J., Emerging Freeze-Drying Process Development and Scale-up Issues, AAPS Pharmscitech., 12: 372-378 (2011).
[6] Wang Z., Finlay W., Peppler M., Sweeney L., Powder Formation by Atmospheric Spray-Freeze-Drying, Powder Technol., 170: 45-52 (2006).
[7] Sebastião I.B., Robinson T.D., Alexeenko A., Atmospheric Spray Freeze-Drying: Numerical Modeling and Comparison with Experimental Measurements, J. Pharm. Sci., 106: 183-192 (2017).
[8] Van't Land C., "Industrial Crystallization of Melts", CRC Press (2004).
[9] Cheng N.-S., Comparison of Formulas for Drag Coefficient and Settling Velocity of Spherical Particles, Powder Technol., 189: 395-398 (2009).
[10] Smith J., Stammers E., Janssen L., Physical Transport Phenomena I, Delft University Press: Delft, 106: 91-92 (1981).
[11] Bergman T.L., Incropera F.P., Fundamentals of Heat and Mass Transfer, John Wiley & Sons, Inc. (2011).
[12] Boretzky W., Schmelzgranulierung‐ein Neues Verfahren Zur Bildung Fester Kügelchen Mit Definiertem Korn Aus Schmelzen, Eur. J. Lipid Sci. Technol., 69: 263-268 (1967).