Investigation of Loading and Controlled Release of a Anti Arrhythmic Drug in a Metal Organic Framework

Document Type : Research Note


1 Chemical Engineering Faculty, Tarbiat Modares University, Tehran, I.R. IRAN

2 Chemical Department, Tarbiat Modares University, Tehran, I.R. IRAN


New drug delivery systems are considered as a destructive technology in diagnosis and treatment of disease. Metal Organic Frameworks (MOFs), as a relatively new crystalline nano porous material family have demonstrated promising horizon in drug delivery field due to their unique properties, such as high pore volume, and regular porosity, and the presence of tunable organic linkers within the framework which allow modulation of the pore sizes. This study investigates the potential of an anionic structure belongs to this family in absorption and delivery of a cationic antiarrhythmic drug, Procainamide hydrochloride. Procainamide hydrochloride has a short half-life in vivo and must be dosed every 3-4 hours. Therefore, it is an ideal candidate for controlled release administration. For this initial study, an anionic metal-organic framework formulated as {Zn3(Benzenedicarboxilate)4Dimethylammomium2.8Dimethylformamide} was chosen. This structure has a thermal stability (decomposition point is above 300C), and regular porosity. Cationic drug was introduced in to the pores through a cationic exchange process with dimethyl ammonium cations. Maximum loading (7.36%) was achieved after one week. Steady drug release was observed after 24 hours; and more than 70% drug release was obtained after 72 hours.


Main Subjects

[1] Ma Z., Moulton B., Recent Advances of Discrete Coordination Complexes and Coordination Polymers in Drug Delivery, Coordination Chemistry Reviews, 255(15-16): 1623-1641 (2011).
[2] Horcajada P., Serre C., Vallet-Regí M., Sebban M., Taulelle F., FérecyGl, Metal–Organic Frameworks as Efficient Materials for Drug DeliveryAngewandteChemie International Edition, 45(36): 5974-5978 (2006).
[3] Meek S.T., Greathouse J.A., Allendorf M.D.,Metal-Organic Frameworks: A Rapidly Growing Class of Versatile Nanoporous Materials, Advanced Materials, 23(2): 249-267 (2011).
[4] An J., Geib S.J., Rosi N.L., Cation-Triggered Drug Release from a Porous Zinc−Adeninate Metal−Organic Framework, Journal of the American Chemical Society, 31(21): 8376-8377 (2009).