Effect of Formulation Parameters on Skin Flux of Demopressin Microemulsion

Soroushnia, Arezo; Ganji, Fariba; Taghizadeh, Seyed Mojtaba

Effect of Formulation Parameters on Skin Flux of Demopressin Microemulsion

Document Type : Research Note

Authors

¹ Biomedical Engineering Group, Chemical Engineering Faculty, Tarbiat Modares University, P.O. Box 14155-143 Tehran, I.R. IRAN

² Novel Drug Delivery Systems Department, Polymer Science Faculty, Iran Polymer and Petrochemical Institute, P.O. Box 14965-115 Tehran, I.R. IRAN

Abstract

Transdermal drug delivery systems are considered in recent years as a promising alternative to oral delivery and hypodermic injections.The present work reports on the development of water-in-oil (w/o) emulsions for the transdermal administration of desmopressin acetate. Microemulsion components included: Tween80 and Span80 (surfactants), 1-decanol (co-surfactant), and isopropyl myristate (oil phase). The effects of formulation components, hydrophilic-lipophilic balance (HLB,7-9 ), ratio of surfactants and co-surfactant mixture to oil phase (S_mix/oil,5:5-7:3) and ratio of surfactants to co-surfactant (S/Cs, 2:1- 5:1) on skin flux was evaluated using Design-Expert software 7.0.0. It was concluded that skin flux was increased when S/Cs and S_mix/oil were decreased and by increasing HLB skin flux enhanced. The following optimized formulation was obtained by the software: HLB = 8, S/Cs = 3, and S_mix/oil = 5.46. Stability and skin permeation of optimized formulation was measured. Based on the results of this research, by reducing the viscosity and increasing the system polarity, drug skin flux of microemulsion increases. Studies of skin permeation show that transdermal drug delivery of large-molecule drugs because of small dimensions and ingredients that act as skin enhancers are possible.

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