Synthesis of New Thiophene Derivatives and Investigation of the Antioxidant and Antimicrobial Properties of the Synthesized Derivatives: Application of Magnetic Iron Oxide Nanoparticles Prepared from Orange Peel Extract

Document Type : Research Article

Authors

1 Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, I.R. IRAN

2 Department of Chemistry, Payame Noor University Tehran, I.R. IRAN

3 Department of Chemistry, Firoozkooh Branch, Islamic Azad University, Firoozkooh, I.R. IRAN

Abstract

In this research, the synthesis of new thiophene derivatives with multicomponent reactions of isothiocyanate, ethyl bromopyruvate, 1,3-dicarbonyl compounds, and the catalytic amount of magnetic iron oxide nanoparticles prepared from orange peel extract in water as solvent was investigated. The yield of the synthesized derivatives in these conditions is very good and the reaction time is also short. To confirm the structure of iron oxide magnetic nanoparticles, a Scanning Electron Microscope (SEM) and X-Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Energy Diffraction X-ray (EDX) spectroscopy, and Vibrating Sample Magnetometer ( VSM) were used. Also, the antioxidant activity of some synthesized derivatives was studied using DPPH radical and iron Reduction Activity Potential (FRAP) test. Also, the antimicrobial activity of some synthesized compounds using disc diffusion tests on gram-positive bacteria and Gram-negative was investigated. Easy separation of the catalyst, carrying out the reaction in green solvent and precipitation of the product in water, easy separation of the product and catalyst, and preparation of the catalyst in the green method are among the advantages of this method is the synthesis of thiophene derivatives. Also, the investigation of the antioxidant and antimicrobial properties of some synthesized compounds showed that these compounds have good antioxidant and antimicrobial properties.

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References

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