Synthesis and Characterization of Iron Magnetic Nanocomposite Super-Absorbent Hydrogels Based on Modified Xanthan Gum using Acrylic Acid

Document Type : Research Article

Authors

Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, I.R. IRAN

Abstract

In this research, the superabsorbent hydrogel based on natural xanthan gum was synthesized using acrylic acid as a monomer, ammonium persulfate as initiator and magnetic iron oxide nanoparticles as a cross-linking agent. The synthesized hydrogel was evaluated by infrared spectroscopy and scanning electron microscopy. All variables affecting the swelling capacity of the hydrogel including the concentration of cross-linking agent, initiator, and monomer to xanthan weight ratio were optimized. The absorption of the optimized sample was 330 g/g. For examining the quality of the synthesized hydrogel, the absorption of the sample in different salt solutions and its swelling behavior in different pH values were measured. The optimized sample showed minimal changes in pH values from 5-11. Furthermore, in order to study the drug delivery, Diclofenac Sodium was used in two acidic and alkaline buffer environments. Within first 5 hours, the initial drug was released from the optimized sample at pH=8.

Keywords

Main Subjects


[1] Hoffman A.S., Hydrogels for Biomedical Applications, Adv. Drug Del. Rev., 43: 3-12 (2002).
[2] Pourjavadi A., Kurdtabar M., Colagen-Based Highly Porous Hydrogel Without any Porogen: Synthesis and Characteristics. Eur. Polym. J., 43: 877-889 (2007).
[3] خوئی، سپیده؛ کردانی، مریم؛ هیدروژل‌ها به عنوان حامل در سامانه‌های دارورسانی کنترل شده، مجله بسپارش، (2)2: 16 تا 27 (1391).
[4] Pourjavadi A., Hosseinzadeh H., Synthesis and Properties of Patially Hydrolyzed Acrylonitrile-co-acrylamide Superabsorbant Hydrogel, Bull. Korean Chem. Soc., 31: 3163-3172 (2010).
[5] Gulerz S., Al-Assaf S., Phillips G., Hydrogels: Methods of Preparation, Characterization and Applications, ‎In A. Carpi (Ed.),"Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications", (pp. 117-150), InTech, Rijeka, Croatia.
[6] Deligkaris K., Tadele, T.S., Hydrogel Based Devices for Biomedical Application, Sens. Actuators B, 147: 765-774 (2010).
[9] Kurdtabar M., Peyvand Kermani Z., Bagheri Marandi G., Synthesis and Characterization of Collagen-Based Hydrogel Nanocomposites for Adsorption of Cd2+, Pb2+, Methylene Green and Crystal Violet, Iran Polym. J., 24: 791-803 (2015).