Overview of Mesoporous Silica Nanoparticles Application as Drug Delivery System

Document Type : Review Article

Authors

1 Food and Agriculture Division, Food and Agriculture Department, Standard Research Institute, Iranian National Standards Organization, P.O. Box 31745-139 Karaj, I.R. IRAN

2 Biomedical Engineering Division, Faculty of Chemical Engineering, Tarbiat Modars University, P.O. Box 14115-143 Tehran, I.R. IRAN

Abstract

In recent years, research on mesoporous materials and different methods of preparation and synthesize of them is developed. These materials have had rapid and successful growth in different applications of various processes. Among mesoporous materials, regular mesoporous silica materials have attracted the attention of biotechnology researchers. In fact, the most widely used mesoporous materials in different industries and processes. These materials are used as adsorbents for the separation of biologically active molecules in food, as a preservative to stabilize enzyme, as a carrier in a drug delivery system and as a catalyst in the petroleum industry, etc. Controlled release systems are based-on mesoporous silica nanoparticles, capable of carrying different types of host molecules. Usually, drug loading is about 100 mg per gram of MSN.Mesoporous silica nanoparticles for drug delivery in the site-specific and controlled delivery of drugs, genes and other therapeutic factors such as antioxidants can be used. In this review article, the synthesize of mesoporous silica nanoparticles from materials, methods of structural properties control, and functionalization of them for applying in biological drug and biotechnology and also, advantages of mesoporous silica nanoparticles, biocompatibility and their uptake mechanism by host cells In vitro are described.

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Main Subjects

References

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