Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

Production and Quality Control of Copper-62/Zinc-62 Radiopharmaceutical Generators (ParsCuGen) in Iran

Document Type : Research Article

Author
Seyed Yousef Fazaeli
AEOI, Teahran, I.R. Iran
Abstract
This paper presents the results of a national research project entitled “Production and quality control of copper-62/zinc-62 radiopharmaceutical generators for positron emission tomography purposes “which has been implemented for the first time in the nuclear science and technology research institute. In this project, after verifying various nuclear codes for cyclotron production, multiple purification chemical reactions and target plating using tetrachloroauric acid,, The industrial scale of  zinc-62 chloride (5 Curie per production) with purity of 99/98% was prepared.Quality control of the prepared radionuclide was done after the production process. Then, the products were loaded on three different types of generators and was ready to send to nuclear medicine centers for clinical use.
Keywords
Radiopharmaceutical generators
Copper-62/zinc-62 radionuclides
cyclotron
Positron emission tomography

Subjects

[1] Packard A.B., Lipophilic Cationic Copper Complexes as PET Radiopharmaceuticals, Int. J. Labeled. Compd & Radiopharm, 40: 484-486 (1997).
[2] Asabella A.,  Lucio Cascini G., Paparella C.,  Notaristefano A.,  Rubini G., The Copper Radioisotopes: A Systematic Review with Special Interest to 64Cu, BioMed Research International, 9: 1-9 (2014). 
[3] Shelton M.E., Green M.A., Mathias C.J., Welch M.J., Kinetics of Copper-PTSM in Isolated Hearts: A Novel Tracer for Measuring Blood Flow with Positron Emission Tomography, J. Nucl. Med., 30(11): 1843-1847 (1989).
[4] http://nucleardata.nuclear.lu.se/toi/nuclide.asp?iZA=300062.http://nucleardata.nuclear.lu.se/toi /nuclide.asp?iZA=300062
[5] Piel H., Qai S.M., St.ocklin G., Excitation Functions of (p,xn)-Reactions on natNi and Highly Enriched 62Ni: Possibility of Production of Medically Important Radioisotope 62Cu at a Small Cyclotron, Radiochim. Acta., 57:1-5 (1992).
[6] Szelecsenyi F., Suzuki K., Kovacs Z., Takei M., Okada K., Production Possibility of 60, 61, 62 Cu Radioisotopes by Alpha Induced Reactions on Cobalt for PET Studies, Nucl. Instrum. Methods B., 187: 153-163 (2002).
[7] Robinson G.D., Zielinski F.W., Lee A.W., The Zinc-62/copper-62 Generator: a Convenient Source of Copper-62 for Radiopharmaceuticals, Int. J. Appl. Radiat. Isot., 31(2), 111-116 (1980).
[8] Wong T.Z., Lacy J.L., Petry N.A., Hawk T.C., Sporn T.A., Dewhirst M.W., Vlahovic G., PET of Hypoxia and Perfusion with 62Cu-ATSM and 62Cu-PTSM Using a 62Zn/62Cu Generator, American Journal of Roentgenology, 190: 427-432 (2008). 
[9] http://www.proportionaltech.com/new_site/?option=com_content&view=article&id=45&Itemi d=56, NIH under the Project Name Improved Production of 62Zn for PET Imaging with62Cu".https://www.proportionaltech.com/pages/products
[10] J, L. Lacy, Nanogenerator, Patent Number: WO 2011143514 A2, (2011).
[11] Ng Y.,  Lacyb J.L.,  Fletchera J.W., Green M.A., Performance of a 62Zn/62Cu Microgenerator in Kit-Based Synthesis and Delivery of [62Cu]Cu–ETS for PET Perfusion Imaging, Applied Radiation and Isotopes, 91: 38 (2014).
[12] Ghandi M., Feizi S., Ziaie F., Fazaeli Y., Synthesis, Characterization and in Vivo Evaluation of [62Zn]–Benzo-δ-Sultam Complex as a Possible PET Imaging Agent, Annals of Nuclear Medicine, 28: 880-890 (2014).
[13] Fukumura T., Okada K., Suzuki H., Nakao R., Mukai K., Szelecsenyi F., Kovacs Z., Suzuki K., An Improved 62Zn/62Cu Generator Based on a Cation Exchanger and Its Fully Remote-Controlled Peparation for Clinical Use, Nucl. Med. Biol., 33(6): 821-827 (2006).