Design, Synthesis, and Identification of the New Indole-Isoxazole Carbohydrazide Structure

Document Type : Research Article

Authors

1 Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, I.R. IRAN

2 Department of Medicinal Chemistry, School of Pharmacy, International Vice-Chancellor Office, Iran University of Medical Sciences, Tehran, I.R. IRAN

Abstract

N-acyl hydrazones (NAH) and carbohydrazide derivatives have shown unique therapeutic properties. There is also, a growing interest in designing and evaluating the biological activity of these compounds and their derivatives to investigate their role as a novel structure in medicinal chemistry researches. Considering the importance of carbohydrazide derivatives, the indole-based structures, and isoxazole ring in drug design, The SAR of the active compounds in anti-Alzheimer, anti-cancer, and antiplatelet aggregation activity, and merits further investigation to find the optimal lead structures with maximum biological activity. In this study, the design, synthesis, and identification of the new Indole-isoxazole rings based carbohydrazides were desired. The synthesis started from 3-acetyl Indole, by using various reactants and reaction conditions (solvent, temperature), to obtain 5- (1-methyl-1-indole-3-yl) isoxazole-3-carbohydrazide as a novel compound that would be used as a fundamental structure in drug design. All structures were identified and approved at each step using spectrophotometer methods such as FT-IR, 1H NMR, and Mass.

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References

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Nashrieh Shimi va Mohandesi Shimi Iran
Volume 38, Issue 3 - Serial Number 93
October 2019
Pages 153-162

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