Investigation on Theoretical and Experimental Parameters in The Production and Quality Control of Zinc-65 Radioactive Source

Document Type : Research Article

Authors

1 Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Tehran, I.R. IRAN

2 Mazandaran University, Babolsar, I.R. IRAN

Abstract

Zinc-65 radioactive source was produced for medicine, agriculture, and industrial applications in Nuclear Science and Technology Research Institute. According to available facilities, 65Cu(p, n)65Zn reaction was applied. The incident proton beam energy was obtained via Alice 91 and Talys 1.0 nuclear codes and Srim-2012 code was used for the determination of target thickness. Considering the obtained results, a 190 μm target was bombarded with a 150 μA current of 29.8 MeV proton beam for 7 hours. Finally, zinc-65 was separated with chemical methods based on the ion-exchange chromatography method and zinc-65 radioactive sources with radioactivity of 402 µCi were produced.

Keywords

Main Subjects

References

[1] Rowshanfarzad P., JaLiLian A., Sabet M., Production and Quality Control of 65Zn Radionuclide, NukLeonika, 50: 97-103 (2005).
[2] Van AmmeL R., Pommé S., Sibbens G., ExperimentaL Verification of the Half-Life of 65Zn, Applied Radiation and Isotopes, 60: 337-339 (2004).
[3] Sabet M., Rowshanfarzad P., JaLiLian A., Ensaf M., Rajamand A., Production and Quality Control of 66Ga Radionuclide, NukLeonika, 51: 147-154 (2006).
[4] W. L. Dunn, ShuLtis J.K., "ExpLoring Monte CarLo Methods", ELsevier, (2011).
[5] ZiegLer J F., Biersack J. P., Littmark U., "The Code of SRIM {The Stopping and Range of Ions in Matter", IBM Research, New York, USA, (2006).
[6] Andrade E., Canto C.E., Rocha M.F., Calibration of an Analyzing Magnet Using the 12C(d, p0)13C Nuclear Reaction with a Thick Carbon Target, Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 406: 38-41 (2017).
[7] Sadeghi M., Kakavand T., Mokhtari L., GhoLamzadeh Z., Determination of 68Ga Production Parameters by Different Reactions Using ALICE and TALYS Codes. Pramana: Journal of Physics, 72:335-341 (2009).
[8] Ghandi M., Feizi Sh., Ziaie F., FazaeLi Y., Notash B., Synthesis, Characterization and In Vivo Evaluation of [62Zn]–benzo-δ-suLtam CompLex as a PossibLe Pet Imaging Agen, Annals of Nuclear Medicine, 28: 880-890 (2014).
[9] GhoLipour N., JaLiLian A.R., FazaeLi Y., Sabzevari O., Moradkhani S., BoLourinovin F., KhaLaj A., Development Of [62Zn/62Cu]-DOTA-Rituximab As A Possible Novel In Vivo PET Generator for Anti-CD20 Antigen Imaging, Radiochimica Acta, 102: 1035-1045 (2014).
[10] فاضلی، سید یوسف؛ تولید و کنترل کیفی ژنراتورهای رادیو دارویی روی-62/مس-62 (ParsCuGen) در ایران، نشریه شیمی و مهندسی شیمی ایران، (1)36: 169 تا 174 (1396)

Files

Share

How to cite

Statistics