Design, Simulation, and Techno-Economic Analysis of Biobutanol Production: A Review

Document Type : Review Article


1 Industrial Biotechnology Group, Department of Chemical Engineering, Isfahan University of Technology, Isfahan, I.R. IRAN

2 Faculty of Engineering, Department of Chemical Engineering, University of Isfahan, Isfahan, I.R. IRAN


Biobutanol has been introduced as an advanced renewable fuel. Some of the properties of butanol, e.g., complete miscibility with gasoline, high heating value, and immiscibility in water, are unique and superior to other biofuels such as ethanol and biomethane. Biobutanol has only been produced at the laboratory scale and its production on a commercial scale still faces many challenges. In the current study, recent research on the techno-economic analysis of biobutanol production, including process simulation and design, are reviewed. Extensive research has been conducted on the production of butanol from lignocellulose materials, a low-cost feedstock, that is not competing with food sources. However, the results show that the cost of butanol production from non-lignocellulosic materials is lower than that from lignocelluloses. Furthermore, it can be concluded that commercial butanol production is facilitated by changing some of the process parameters. These parameters include pretreatment conditions, fermentation mode of operation, enhancement of bacterial performance using genetic engineering, and recovery and purification of butanol from the fermentation broth.


Main Subjects

[1] پاکدل، علی؛ جعفری نصر، محمدرضا، شبیه سازی و بررسی پارامتری چرخه تجمیعی متمرکز کننده­ های سهموی خورشیدی و چرخه آلی رانکین برای تولید توان الکتریکی، نشریه شیمی و مهندسی شیمی ایران، (3)33: 65 تا 83 (1393).
[2] Naik S.N., Goud V.V., Rout P.K., Dalai A.K., Production of First and Second Generation Biofuels: A Comprehensive Review, Renew. Sust. Energy Rev, 14: 578–97 (2010).
 [3] نجفی، بهمن؛ مدل‌سازی سینتیک شیمیایی تولید سوخت بیودیزل از روغن پسماند رستوران، نشریه شیمی و مهندسی شیمی ایران، (2)30: 25 تا 33 (1390).
 [4] شکرکار، هانیه ؛ ابراهیمی، سیروس، زمانی، مهدی؛ بررسی تجربی و مدل سازی هیدرولیز آنزیمی ریز جلبک به منظور تولید اتانول با استفاده از شبکه عصبی، نشریه شیمی و مهندسی شیمی ایران، (2)36: 191 تا 181 (1396).
[5] Saeed Khan S., Novel Pretreatment Methods to Improve Enzymatic Saccharification of Sugarcane Bagasse: A Report, Iran. J. Chem. Chem. Eng. (IJCCE), 37(5): 224-234 (2018).
[6] Green EM., Fermentative Production of Butanol- the Industrial Perspective, Curr. Opin. Biotechnol, 22: 337–343 (2011).
[7] Eyidogan M., Ozsezen A. N., Canakci M., and Turkcan A., Impact of Alcohol Gasoline Fuel Blends on the Performance and Combustion Characteristics of an SI Engine, Fuel, 89(10): 2713–2720 (2010).
[8] Karimi K., Tabatabaei M., Horváth IS., Kumar R., Recent Trends in Acetone, Butanol, and Ethanol (ABE) Production, Biofuel Research Journal, 2(4): 301-308 (2015).
[9] Chiao J.S., Sun Z.-H., Histoournalry of the Acetone-Butanol-Ethanol Fermentation Industry in China: Development of Continuous Production Technology, Journal of Molecular Microbiology and Biotechnology, 13(1-3): 12-14 )2007(.
[11] Shafiei M., Kabir M.M., Zilouei H., Horváth I.S., Karimi K., Techno-Economical Study of Biogas Production Improved by Steam Explosion Pretreatment, Biofuel Technologies 148: 53-60 (2013).
[12] Menon V., Rao M., Trends in Bioconversion of Lignocellulose: Biofuels, Platform Chemicals and Biorefinery Concept, Progress in Energy and Combustion Science, 38: 522-550 (2012).
[13] Amiri H., Karimi K., Bankar S., Granström T.," Biobutanol from Lignocellulosic Wastes".  in “lignocellulose-Based Bioproducts”, 289-324, Springer (2015)
[15] Karimi K., Shafiei M., Kumar R., Progress in Physical and Chemical Pretreatment of Lignocellulosic Biomass, Biofuel Technologies, 53-96 (2013).
[16] Procentesea A., Guidaa T., Raganatia F., Olivieri G., Salatino P., Marzocchella A.N., Process Simulation of Biobutanol Production from Lignocellulosic Feedstocks, Chemical Engineering Transactions, 38: 343-348 )2014(.
[17] Karimi K., Amiri H., Zilouei H., Organosolv Pretreatment of Rice Straw for Efficient Acetone, Butanol, and Ethanol Production, Bioresource Technology, 152: 450-456 (2014).
[20] Sun Y, Cheng J., Hydrolysis of Lignocellulosic Materials for Ethanol Production: A Review, Bioresource Technology, 1-11 (2002).
[21] Galbe M., Zacchi G., A Review of the Production of Ethanol from Softwood, Applied Microbiology and Biotechnology, 59: 618-628)2002(.
[23] Farmanbordar S., Karimi K., Amiri H., Simultaneous Organosolv Pretreatment and Detoxification of Municipal Solid Waste for Efficient Biobutanol Production, Bioresource Technology, 270: 236-244.
[24] Larsson S., Palmqvist E., The Generation of Fermentation Inhibitors During Dilute Acid Hydrolysis of Softwood, Enzyme and Microbial Technology, 24: 151-159 (1999).
[25] Keis S., Shaheen R., Jones DT., Emended Descriptions of Clostridium Acetobutylicum and Clostridium Beijerinckii, and Descriptions of Clostridium Saccharoperbutylacetonicum Sp. Nov. and Clostridium Saccharobutylicum Sp. Nov, International Journal of Systematic and Evolutionary Microbiology, 51: 2095-2103 (2001).
[27] Asadollahi MA., Rismani-Yazdi H., The Use of Non-Treated Starch for Butanol Production by Clostridium Acetobutylicum, Biological Journal of Microorganism, 4 (14): 1-8.
[28] Mirfakhar M., Asadollahi MA., Amiri H., Karimi K. Phenolic Compounds Removal from Sweet Sorghum Grain for Efficient Biobutanol Production Without Nutrient Supplementation, Ind. Crop. Prod. 108: 225-231(2017).
[29] Kheyrandish M., Asadollahi MA., Jeihanipour A., Doostmohammadi M., Rismani-Yazdi H., Karimi K., Direct Production of Acetone–Butanol–Ethanol from Waste Starch by Free and Immobilized Clostridium Acetobutylicum, Fuel, 142(15): 129-133 (2015).
[30] Gonçalvesa B.J., Crena E., Windmöllerb D., Activated Carbon-Loaded Polydimethylsiloxane Membranes for the Pervaporation of 1-Butanol from Aqueous Solutions, Materials Research, 22(1): (2019).
[31] Tao L., He X., Tan Eric C. D., Zhang M., Aden A., Comparative Techno-Economic Analysis and Reviews of N-Butanol Production from Corn Grain and Corn Stover, Biofuels, Bioproducts and Biorefining, 8(3): 342-361 (2014).