Effective Method for Knoevenagel Condensation Catalyzed by Acetoguanamine Supported on Magnetic Nanoparticles

Document Type : Research Article


1 Department of Chemistry, Hakim Sabzevari University, Sabzevar, I.R. IRAN

2 Department of Physics, Hakim Sabzevari University, Sabzevar, I.R. IRAN

3 Young Researchers and Elite Club, Islamshahr Branch, Islamic Azad University, Islamshahr, I.R. IRAN


A green and effective method for the synthesis of benzylidene malononitrile derivatives via condensation of different aldehyde and malononitrile in the presence of Acetoguanamine supported on CoFe2O4 magnetic nanoparticles coated by silica gel as a new catalyst at room temperature with ethanol and water solvent was reported. The simple separation of products from the reaction mixture, the improvement of product yields, the short reaction time, and the use of solvents that have relatively less environmental pollution, the easy reaction method, the recoverable and reusable catalysts are the advantages of this method. The 6-methyl-1,3,5-triazine-2,4-diamine supported on CoFe2O4 magnetic nanoparticles coated by silica gel could be recycled five times without significant loss of its catalytic activity. All products were characterized by spectral data and by comparison with authentic samples reported in the literature.


Main Subjects

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