Evaluation of drug delivery properties of UMCM-150 metal-organic framework based on iron and copper: Delivery and release of acetaminophen

Document Type : Research Article

Authors

1 Master student of Chemical Engineering. Babol Noshirvani University of Technology.

2 Assistant professor in Chemical Engineering Department, Babol Noshirvani University of Technology.

3 Assistant professor in Chemistry, Science Department, , Babol Noshirvani University of Technology

Abstract

In this study, two metal-organic frameworks of UMCM-150 entitled Fe1Cu2(BHTC)2 and Cu3(BHTC)2 were used to delivery and release of acetaminophen as a non-steroidal drug. These frameworks were synthesized using solvothermal method. The crystallinity of the synthesized metal-organic frameworks was confirmed by SEM and XRD analyses. The stability of particles was determined by DLS analysis and their thermal stability was evaluated by TGA analysis. Also, the surface area, volume and size of pores were also measured by BET analysis that indicated a particularly suitable surface area and porosity of the pores. After loading acetaminophen in carriers with 25.29% efficiency for Fe1Cu2(BHTC)2, and 10.82% for Cu3(BHTC)2, the release of drug was evaluated in saline phosphate buffer solution at pH = 7.4. The release efficiencies of Fe1Cu2(BHTC)2 and Cu3(BHTC)2,were obtained 41.45 and 57.5%, respectively. Also, various kinetic models (zero, first order, Higuchi and Korsmeyer-Peppas) were used to interpret the release data that the Korsmeyer-Peppas model (R2>0.92) reasonably described the release results. Based on the obtained results, both synthesized metal organic frameworks are promising option for the delivery and slow release of acetaminophen.

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Main Subjects

Nashrieh Shimi va Mohandesi Shimi Iran

Articles in Press, Accepted Manuscript
Available Online from 18 November 2020

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