Synthesis, characterization and biological properties of Cu(II) mixed-ligand complexes incorporating asymmetric Schiff base ligands

Document Type : Research Article


1 department of chemistry, shahid Bahonar University of Kerman, Kerman, Iran

2 Department of science, Shahid bahonar university of kerman, kerman, Iran

3 department of science, shahid bahonar university of kerman. Iran


In this research, two tridentate Schiff base ligands 3-((2‐hydroxy‐3 methoxybenzylidene) amino)-2-methylquinazolin-4(3H)-one [HL1] and 3-((5-bromo-2-hydroxy-3-methoxybenzylidene)amino)-2-methylquinazolin-4(3H)-one [HL2] and their mixed-ligand complexes [Cu(L1)(bipy)] and [Cu(L2)(bipy)]; (bipy=2,2 bipyridine) were synthesized and fully characterized using spectroscopic techniques such as FT-IR, UV-Vis, and mass spectroscopy techniques. The element analysis, molar conductivity and melting points of these compounds were also determined. Antibacterial activities of the ligands and Cu(II) complexes were evaluated against gram positive bacteria Staphylococcus aureus, Bacillus cereus, gram negative bacteria Escherichia coli and Pseudomonas aeruginosa. According to the results, complexes showed significantly higher antibacterial activities compared to their related ligands. Keywords: Schiffbase,Cu(II) complex, spectral technique, antibacterial activity


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