Production and Experimental Examination of Ultravist Coated Tungsten Trioxide Nanoparticles as a Contrast Agent in Computed Tomography Imaging

Document Type : Research Article


1 Department of Biomedical Engineering, Najafabad Branch, Islamic Azad University, Najafabad , Iran.

2 Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran

3 Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.


Computed tomography imaging can help in the diagnosis of diseases in the early stages and provide important information about the pathology of processes. Computed tomography imaging relies heavily on the development of complex contrast agents to detect biological processes even in the cells. Nano contrast agents have a significant advantage over iodine-based molecules like creating high contrast and long circulation in blood. In this study, Tungsten trioxide nanoparticles were fabricated by the co-precipitation method to improve the contrast in computed tomography images; and to stabilize and increase contrast, Ultravist was used as coating utilizing the ultrasonic bath method. To determine the characteristics of Tungsten trioxide nanoparticles, scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffraction test (XRD), vibrating sample magnetometer (VSM), dynamic light scattering (DLS), and zeta potential were performed.

The result of the SEM test indicates nanoparticles morphology. The result of X-ray diffraction analysis showed that nanoparticles have the chemical formula (WO3) and have more adjustment with Monoclinic Crystal system coding JCPDSNO-43-1035. The vibration Sample Magnetometer proved that the nanoparticles are Ferromagnetism agents. To illustrate the suspension stability and also particle dimension, zeta-potential and optical Dynamic-Dispersion have been used. Zeta potentiality was 25±2 Millivolt (mv) and optical Dynamic-Dispersion was 383.7, 2616.2 nm. And finally, Scanning findings have been compared with iodine-based molecules indicating that in similar density, nanoparticles (WO3) with Ultravist cortex have higher contrast and better image clarity.


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