Dispersive solid phase microextraction of omeprazole and dimenhydrinate by graphene oxide modified with polyphenols of rosemary

Articles in Press

Document Type : Research Article

Authors

1 Department of chemistry, Faculty of science, Ilam university, Iran

2 Department of Chemistry, Faculty of Science, Ilam University, Iran

3 Department of chemistry, Faculty of science, Lorestan university, Khoramabad, Iran

Abstract

In this project, a simple and low-cost method for the simultaneous extraction of dimenhydrinate and omeprazole from serum, urine and pharmaceutical samples is reported. The proposed method is based on the dispersive solid phase microextraction by optimized graphene oxide adsorbent. The polyphenols of rosemary extract are polymerized in the presence of amino acid lysine and formaldehyde and functionalized the surface of graphene oxide. Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscope (FE-SEM), X-ray Diffraction (XRD), Energy Dispersion Spectroscopy (EDS) and Raman were used to characterize the synthesized composite. Simultaneous analysis of dimenhydrinate and omeprazole was performed using high-performance liquid chromatography equipped with ultraviolet/visible detector (HPLC-UV). The results of the evaluation of the work lead to the linearity of 1-400 μg/L, detection limits 0/33-0/48 μg/L, and the correlation coefficients (R2) more than 0/9991 for both species. The recovery percentage (more than 94/3) obtained from the analysis of real blood serum and urine samples indicates the high accuracy of the method and the absence of matrix effect. The F-test was used to compare the precision and the t-test to compare the accuracy of the proposed method with ultraviolet/visible spectroscopic methods on Dimanhydrinate tablets and Omeprazole capsules and the results showed that there is no significant difference between the answers obtained by the two methods.

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Main Subjects

Nashrieh Shimi va Mohandesi Shimi Iran

Articles in Press, Accepted Manuscript
Available Online from 06 December 2023

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