Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

Dispersive Solidphase Microextraction of Dimenhydrinate and Omeprazole using Graphene Oxide Modified with Rosemary Extract Polyphenols

Document Type : Research Article

Authors
Seyedeh Hoda Mousavi 1
Tahere Khezeli 1
Ali Daneshfar 2
1 Department of Chemistry, Faculty of Basic Sciences, Ilam University, Ilam, Iran
2 Department of Chemistry, Lorestan University, Khoramabad, Iran
Abstract
In this project, a simple and low-cost method for the simultaneous extraction of dimenhydrinate and omeprazole from blood serum, urine and pharmaceutical samples is reported. The proposed method is based on dispersive solid phase microextraction by modified graphene oxide adsorbent. The polyphenols of rosemary extract are polymerized in the presence of amino acid lysine and formaldehyde and functionalize the surface of graphene oxide. Fourier transform-infrared spectroscopy (FT-IR), field emission-scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), energy dispersive spectroscopy (EDS) and Raman were used to identify the synthesized composite. Simultaneous analysis of dimenhydrinate and omeprazole was performed by high performance liquid chromatography equipped with ultraviolet/visible detector (HPLC-UV). The results of the work evaluation led to the achievement of a linear range of 1-400 µg/L, detection limits of 0.33-0.48 µg/L, and the coefficient of determination (R2) of more than 0.9991 for both analytes. The recovery % (more than 94.3) obtained from the analysis of real samples of blood serum and urine shows the high accuracy of the method and the absence of matrix effect. The F-test was used to compare the precision and the t-test was used to compare the accuracy of the proposed method with ultraviolet/visible spectroscopy methods on dimenhydrinate tablets and omeprazole capsules, and the results showed that there is no significant difference between the answers obtained from the two methods.
Keywords
Dimenhydrinate
Omeprazole
Dispersive solid phase microextraction
Modified graphene oxide

Subjects

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