Nashrieh Shimi va Mohandesi Shimi Iran

Nashrieh Shimi va Mohandesi Shimi Iran

Fabrication and Investigation of Physical, Chemical, and Mechanical Properties of Carboxymethylcellulose/Cellulose Nanofiber Transdermal Patch to Control the Release of Naproxen

Document Type : Research Article

Authors
Narges Mirzaee 1
Maryam Nikzad 2
Atefeh Araghi 3
Rodrigo Battisti 4
1 Separation Process Group, Chemical Engineering Department, Babol Noshirvani University of Technology, Bobol. I.R. IRAN
2 Department of Separation Processes, Faculty of Chemical Engineering, Noshirvani University of Technology, Babol, Babol, I.R. IRAN
3 Faculty of Veterinary Medicine, Amol University of New Technologies, Amol, I.R. IRAN
4 Federal Institute of Education, Science and Technology of Santa Catarina (IFSC), Criciúma, Santa Catarina, Brazil
Abstract
In this research, for the first time, the effect of cellulose nanofibers in the production of carboxymethyl cellulose-based transdermal adhesive for carrying and controlling the release of naproxen has been studied. This study used cellulose nanofibers isolated from rapeseed straw to make carboxymethyl cellulose/cellulose nanofiber nanocomposite films with different formulations. Examination of the physical properties of the prepared nanocomposites showed that the addition of cellulose nanofibers in the nanocomposite structure caused an increase in the thickness of the nanocomposite film from 65 µm to 86 µm. Also, the water vapor transmission rate of the pure carboxymethyl cellulose film was calculated to be 0.00386 gr/cm.24hr, which decreased to 0.00291 gr/cm.24hr with the addition of cellulose nanofibers, indicating a decrease in the penetration of water molecules into the structure of the prepared nanocomposites. The results of FTIR analysis confirmed the successful drug loading into the film structure. Based on the mechanical properties, the tensile strength for the pure carboxymethylcellulose film was measured to be 13.3 MPa, which increased to 27.1 MPa after adding cellulose nanofibers. The drug loading efficiency of the pure carboxymethylcellulose film was 20%, which increased to 64.3% with the addition of cellulose nanofibers. The drug release kinetics study showed that due to the dense network structure of the nanocomposite resulting from the presence of cellulose nanofibers, the drug release from the nanocomposite films was much slower than that of the pure carboxymethylcellulose film, indicating a slow and controlled drug release by these drug carriers. The findings of this study showed that the prepared nanocomposite films are suitable candidates for the transdermal delivery of naproxen.
Keywords
Carboxy methyl cellulose
Cellulose nanofibers
Transdermal patches
Naproxen Drug loading
Drug release

Subjects

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