Construction of Sensor for Dopamine Detection by Using Microfluidic Paper-Based Analyzers

Document Type : Research Article

Authors

1 Biofuels and Renewable Energy Research Center, Department of Biotechnology, Faculty of Chemical Engineering, Noshirvani University of Technology, Babol, I.R.IRAN.

2 Department of Mechanics, School of Mechanical Engineering, Noshirvani University of Technology, Babol, I.R.IRAN.

3 Department of Electronics, Faculty of Electrical and Computer Engineering, Noshirvani University of Technology, Babol, I.R.IRAN.

Abstract

In this research, a simple and inexpensive colorimetric detection method for dopamine was reported using laser cutting technique on microfluidic paper-based analytical devices. The effect of various factors such as reaction time between dopamine and ferric chloride, sample volume, drying time, pH of phenanthroline solution and volume ratio of ferric chloride / dopamine were investigated and optimized. The optimal values for each of the parameters were 4 min, 1.4, 2.8 and 4.2 μl, 12 min, 7.4 and 2: 1, respectively. From subsequent analyzes using Photoshop software, LOD and LOQ were calculated 0.0171 Mµ and 0.0517 Mµ, and RSD was obtained in the range of 0.12 ٪ to 17 0.17 for n = 5, which shows the good accuracy of this method. Also in this study, the potential of the proposed method as a low cost and fast colorimetric method for dopamine determination in real samples including human blood serum was shown.

Keywords

Main Subjects

References

[1] Hatefi-Mehrjardi A., Beheshti-Marnani A., Askari N., Cu2+ Loaded" Zeolite A"/Nitrogen-Doped Graphene as a Novel Hybrid for Simultaneous Voltammetry Determination of Carbamazepine and Dopamine, Materials Chemistry and Physics, 225: 137-144 (2019).
[2] Rostami S., Mehdinia A., Jabbari A., Intrinsic Peroxidase-Like Activity of Graphene Nanoribbons for Label-Free Colorimetric Detection of Dopamine, Materials Science and Engineering: C, 114: 111034 (2020).
[3] Pirino B.E., Spodnick M.B., Gargiulo A.T., Curtis G.R., Barson J.R., Karkhanis A.N., Kappa-Opioid Receptor-Dependent Changes in Dopamine and Anxiety-Like or Approach-Avoidance Behavior Occur Differentially across the Nucleus Accumbens Shell Rostro-Caudal Axis, Neuropharmacology, 181: 108341 (2020).
[4] Wai J.M., Grassetti A., Slifstein M., Matuskey D., Nabulsi N., Ropchan J., Labaree D., Huang Y., Martinez D., Binge Alcohol Use Is Not Associated with Alterations in Striatal Dopamine Receptor Binding or Dopamine Release, Drug and alcohol dependence, 205: 107627 (2019).
[5] Rasheed P.A., Lee J.-S., Recent Advances in Optical Detection of Dopamine Using Nanomaterials, Microchimica Acta, 184(5): 1239-1266 (2017).
[6] Qi S., Zhao B., Tang H., Jiang X., Determination of Ascorbic Acid, Dopamine, and Uric Acid by a Novel Electrochemical Sensor Based on Pristine Graphene, Electrochimica Acta, 161: 395-402 (2015).
[7] Jothi L., Neogi S., kumar Jaganathan S., Nageswaran G., Simultaneous Determination of Ascorbic Acid, Dopamine and Uric Acid by a Novel Electrochemical Sensor Based on N2/Ar Rf Plasma Assisted Graphene Nanosheets/Graphene Nanoribbons, Biosensors and Bioelectronics, 105: 236-242 (2018).
[8] Zhao H., Zhu Y., Liao F., Gao A., Shao Y., Shao M., Additive-Free Gold Nanoparticles Induced by Gamma Ray Irradiation for Voltammetric Detection of Dopamine, Journal of nanoscience and nanotechnology, 18(7): 4495-4500 (2018).
[9] Ye H., Wang H., Zhang B., Zhao F., Zeng B., Tremella-Like ZnIn2S4/Graphene Composite Based Photoelectrochemical Sensor for Sensitive Detection of Dopamine, Talanta, 186: 459-466 (2018).
[10] Kong D., Zhuang Q., Han Y., Xu L., Wang Z., Jiang L., Su J., Lu C.-H., Chi Y., Simultaneous Voltammetry Detection of Dopamine and Uric Acid in Human Serum and Urine with a Poly (Procaterol Hydrochloride) Modified Glassy Carbon Electrode, Talanta, 185: 203-212 (2018).
[11] Chen Q., Liang C., Zhang X., Huang Y., High Oxidase-Mimic Activity of Fe Nanoparticles Embedded in an N-Rich Porous Carbon and Their Application for Sensing of Dopamine, Talanta, 182: 476-483 (2018).
[12] Šolínová V., Žáková L., Jiráček J., Kašička V., Pressure Assisted Partial Filling Affinity Capillary Electrophoresis Employed for Determination of Binding Constants of Human Insulin Hexamer Complexes with Serotonin, Dopamine, Arginine, and Phenol, Analytica chimica acta, 1052: 170-178 (2019).
[13] Boumya W., Achak M., Bakasse M., El Mhammedi M., Indirect Determination of Dopamine and Paracetamol by Electrochemical Impedance Spectroscopy Using Azo Coupling Reaction with Oxidized 2, 4-Dinitrophenylhydrazine (Dnph): Application in Commercial Tablets, Journal of Science: Advanced Materials and Devices, 5(2): 218-223 (2020).
[14] Liu C., Gomez F.A., Miao Y., Cui P., Lee W., A Colorimetric Assay System for Dopamine Using Microfluidic Paper-Based Analytical Devices, Talanta, 194: 171-176 (2019).
[15] Wang J., Du R., Liu W., Yao L., Ding F., Zou P., Wang Y., Wang X., Zhao Q., Rao H., Colorimetric and Fluorometric Dual-Signal Determination of Dopamine by the Use of Cu-Mn-O Microcrystals and C-Dots, Sensors and Actuators B: Chemical, 290: 125-132 (2019).
[16] Gong M.M., Sinton D., Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application, Chemical reviews, 117(12): 8447-8480 (2017).
[17] Alfihed S., Holzman J.F., Foulds I.G., Developments in the Integration and Application of Terahertz Spectroscopy with Microfluidics, Biosensors and Bioelectronics, 165: 112393 (2020).
[18] LIANG S.-J., Ji-Kai M., Chen G., Dong-Dong Y., Jian-Guang Z., Research and Application Progress of Paper-Based Microfluidic Sample Preconcentration, Chinese Journal of Analytical Chemistry, 47(12): 1878-1886 (2019).
[19] Fu L.-M., Wang Y.-N., Detection Methods and Applications of Microfluidic Paper-Based Analytical Devices, TrAC Trends in Analytical Chemistry, 107: 196-211 (2018).
[20] Nuchtavorn N., Macka M., A Novel Highly Flexible, Simple, Rapid and Low-Cost Fabrication Tool for Paper-Based Microfluidic Devices (Μpads) Using Technical Drawing Pens and in-House Formulated Aqueous Inks, Analytica chimica acta, 919: 70-77 (2016).
[21] Lim W.Y., Thevarajah T.M., Goh B.T., Khor S.M., Paper Microfluidic Device for Early Diagnosis and Prognosis of Acute Myocardial Infarction Via Quantitative Multiplex Cardiac Biomarker Detection, Biosensors and Bioelectronics, 128: 176-185 (2019).
[22] Tseng C.-C., Yang R.-J., Ju W.-J., Fu L.-M., Microfluidic Paper-Based Platform for Whole Blood Creatinine Detection, Chemical engineering journal, 348: 117-124 (2018).
[23] Ruiz-Vega G., Arias-Alpízar K., de la Serna E., Borgheti-Cardoso L.N., Sulleiro E., Molina I., Fernàndez-Busquets X., Sánchez-Montalvá A., Del Campo F.J., Baldrich E., Electrochemical Poc Device for Fast Malaria Quantitative Diagnosis in Whole Blood by using Magnetic Beads, Poly-Hrp and Microfluidic Paper Electrodes, Biosensors and Bioelectronics, 150: 111925 (2020).
[24] Chen Z., Zhang C., Zhou T., Ma H., Gold Nanoparticle Based Colorimetric Probe for Dopamine Detection Based on the Interaction between Dopamine and Melamine, Microchimica Acta, 182(5-6): 1003-1008 (2015).
[25] Nguyen Q.H., Kim M.I., Nanomaterial-Mediated Paper-Based Biosensors for Colorimetric Pathogen Detection, TrAC Trends in Analytical Chemistry, 132: 116038 (2020).
[26] Hao G., Zhang Z., Ma X., Zhang R., Qin X., Sun H., Yang X., Rong J., A Versatile Microfluidic Paper Chip Platform Based on Mips for Rapid Ratiometric Sensing of Dual Fluorescence Signals, Microchemical Journal, 157: 105050 (2020).
[27] Zhou Y., Kablan A., Engelberg D.L., Metallographic Screening of Duplex Stainless Steel Weld Microstructure with a Bipolar Electrochemistry Technique, Materials Characterization, 169: 110605 (2020).
[28] Wang F., Fu C., Huang C., Li N., Wang Y., Ge S., Yu J., Based Closed Au-Bipolar Electrode Electrochemiluminescence Sensing Platform for the Detection of Mirna-155, Biosensors and Bioelectronics, 150: 111917 (2020).
[29] Mesgari F., Beigi S.M., Fakhri N., Hosseini M., Aghazadeh M., Ganjali M.R., Based Chemiluminescence and Colorimetric Detection of Cytochrome C by Cobalt Hydroxide Decorated Mesoporous Carbon, Microchemical Journal, 157: 104991 (2020).
[30] Manmana Y., Chutvirasakul B., Suntornsuk L., Nuchtavorn N., Cost Effective Paper-Based Colorimetric Devices for a Simple Assay of Dopamine in Pharmaceutical Formulations Using 3, 3’, 5, 5’-Tetramethylbenzidine-Silver Nitrate as a Chromogenic Reagent, Pharm. Sci. Asia, 46: 270-277 (2019).
[31] Ghosh R., Gopalakrishnan S., Savitha R., Renganathan T., Pushpavanam S., Fabrication of Laser Printed Microfluidic Paper-Based Analytical Devices for Point-of-Care Applications, AIChE, (2019).
[32] Zhong Z., Wu R., Wang Z., Tan H., An Investigation of Paper Based Microfluidic Devices for Size Based Separation and Extraction Applications, Journal of Chromatography B, 1000: 41-48 (2015).
[33] Aksorn J., Teepoo S., Development of the Simultaneous Colorimetric Enzymatic Detection of Sucrose, Fructose and Glucose Using a Microfluidic Paper-Based Analytical Device, Talanta, 207: 120302 (2020).

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