Supercritical Extraction and Analysis of Cinnamaldehyde from Cinnamon Bark and Investigation of Effective Conditions in Comparison to Other Traditional Methods

Masghati, Shima; Ghoreishi, Seyed Mohammad

Supercritical Extraction and Analysis of Cinnamaldehyde from Cinnamon Bark and Investigation of Effective Conditions in Comparison to Other Traditional Methods

Document Type : Research Article

Authors

Shima Masghati

Seyed Mohammad Ghoreishi

Department of Chemical Engineering, Isfahan University of Technology, Isfahan, I.R. IRAN

Abstract

Research shows that cinnamon essential oil (especially Cinnamaldehyde) can be effective on the treatment of diabetics. So the main purpose of this study was supercritical extraction and experimental investigation of Cinnamaldehyde from cinnamon bark. In this article, a comparison of traditional extraction methods versus the supercritical extraction of cinnamon essential oils was carried out. Then Cinnamaldehyde by using modified supercritical carbon dioxide with a fixed amount of methanol (1ml) was extracted and compared with Soxhlet extraction. Supercritical fluid extraction (SFE) with a static time of 20 minutes and the average particle size (0/674 mm) was used. The effects of variables on the process such as temperature (40- 80 ˚C), pressure (10-30Mpa), carbon dioxide flow rate (1/5 – 2/5 ml/min) and dynamic extraction time (40-120 min) were investigated on yield.

Keywords

Supercritical extraction

Soxhlet extraction

Cinnamaldehyde

Gas chromatography

Operating conditions

Subjects

[1] Atalay M., Laaksonen DE. Diabetes, Oxidative Stress and Physical Exercise, Journal of Sports Science & Medicine: 1(1):1-14 (2002).

[2] Memısoğullari R., Taysı S., Bakan E., Capoglu I., Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus, Cell Biochemistry and Function, 21(3):291-296 (2003).

[3] Raskin P., Jovanovic L., Berger S., Schwartz S., Woo V., Ratner R., Repaglinide/Troglitazone Combination Therapy: Improved Glycemic Control in Type 2 Diabetes, Diabetes Care, 23(7): 979-83 (2000).

[4] Warren R.E., The Stepwise Approach to the Management of Type 2 Diabetes, Diabetes Research and Clinical Practice, 65:S3-S8 (2004).

[5] Ogbera A., Dada O., Adeleye F., Jewo P., Complementary and Alternative Medicine Use in Diabetes Mellitus, West African Journal of Medicine, 29(3): 158-161 (2010).

[6] Elumalai S., Kesavan R., Ramganesh S., Murugesan R., Isolation, Purification and Identification of the Anti-Diabetic Components from Cinnamomum Zeylanicum and Cinnamomum Cassia Bark Oil Extracts, Current Botany, 2(6): 1-7 (2011).

[7] Schmidt E., Jirovetz L., Buchbauer G., Eller G.A., Stoilova I., Krastanov A., et al., Composition and Antioxidant Activities of the Essential Oil of Cinnamon (Cinnamomum Zeylanicum Blume) Leaves from Sri Lanka, Journal of Essential Oil Bearing Plants, 9(2):170-82 (2006).

[8] Faix Š., Faixová Z., Plachá I., Koppel J., Effect of Cinnamomum Zeylanicum Essential Oil on Antioxidative Status in Broiler Chickens, Acta Veterinaria Brno., 78(3):411-417 (2009).

[9] Roy H., Lundy S., Resveratrol, Pennington Nutrition Series, 7:1-4 (2005).

[10] Govender H., "A Comparative Study of Solvent Extraction, Soxhlet Extraction, Steam Distillation, Headspace Analysis and Headspace Solid Phase Microextraction for the Extraction of Volatile Terpenoid Compounds in the Curry Leaf Plant (Murraya Koenigii)", University of KwaZulu, Durban (2010).

[11] ابوالقاسمی، حسین؛ عروجی، رضا؛ مهدویان، محمد؛ وطنی، ضحی؛ پیش‌بینی حلالیت فتوکرمیک رنگی Spiroindolinonaphthoxazine در کربن دی اکسید فوق بحرانی با استفاده از معادله‌های حالت درجه سوم، نشریه شیمی و مهندسی شیمی ایران، (4)26: 105 تا 112 (1386).

[12] Ghoreishi S., Sharifi S., Modeling of Supercritical Extraction of Mannitol from Plane Tree Leaf, Journal of Pharmaceutical and Biomedical Analysis, 24(5):1037-48 (2001).

[13] Ghoreishi S.M., Shahrestani R.G., Ghaziaskar H.S., Experimental and Modeling Investigation of Supercritical Extraction of Mannitol from Olive Leaves, Chemical Engineering & Technology, 32(1):45-54 (2009).

[14] Akgerman A., Erkey C., Ghoreishi S.M., Supercritical Extraction of Hexachlorobenzene from Soil, Industrial & Engineering Chemistry Research, 31(1):333-339 (1992).

[15] Ghoreishi S.M., Bataghva E., Dadkhah A.A., Response Surface Optimization of Essential Oil and Diosgenin Extraction from Tribulus Terrestris Via Supercritical Fluid Technology, Chemical Engineering & Technology, 35(1):133-41 (2012).

[16] Hedayati A., Ghoreishi S., Supercritical Carbon Dioxide Extraction of Glycyrrhizic Acid from Licorice Plant Root Using Binary Entrainer: Experimental Optimization via Response Surface Methodology, The Journal of Supercritical Fluids, 100:209-217 (2015).

[17] Ghoreishi S., Heidari E., Extraction of Epigallocatechin Gallate from Green Tea via Modified Supercritical CO₂: Experimental, Modeling and Optimization, The Journal of supercritical fluids. 72:36-45 (2012).

[18] Jham G.N., Dhingra O.D., Jardim C.M., Valente V.M., Identification of the Major Fungitoxic Component of Cinnamon Bark Oil, Fitopatologia Brasileira, 30(4):404-408 (2005).

[19] Kamaliroosta L., Gharachorloo M., Kamaliroosta Z., KH A.Z., Extraction of Cinnamon Essential Oil and Identification of Its Chemical Compounds, Journal of Medicinal Plants Research, 6(4):609-614 (2012).

[20] Paranagama P., Wimalasena S., Jayatilake G., Jayawardena A., Senanayake U., Mubarak A., A Comparison of Essential Oil Constituents of Bark, Leaf, Root and Fruit of Cinnamon (Cinnamomum zeylanicum Blum) Grown in Sri Lanka, Journal of the National Science Foundation of Sri Lanka, 29(3-4):147-153 (2010).

[21] حسینی، ناصر؛ ملکی، علی اکبر؛ چنگیزی، سعید؛ ناظمی، منا؛ بررسی قابلیت اسانس و فراکشنهای مختلف عصاره متانولی آویشن شیرازی، مریم گلی، رزماری، خالواش و دارچین در مهار رادیکالهای آزاد، مجله دانشگاه علوم پزشکی و خدمات بهداشتی درمانی شهید صدوقی یزد، (1)20: 28 تا 38، (1391).

[22] کمالی‌روستا، لیلا؛ قوامی، مهرداد؛ قرچورلو، مریم؛ عزیزی‌نژاد، رضا؛ استخراج عصاره دارچین و بررسی تاثیر آن بر پایداری روغن آفتابگردان، مجله علوم تغذیه و صنایع غذایی ایران، (1)6: 13 تا 22 (1390).

[23] Wong Y., Ahmad-Mudzaqqir M., Wan-Nurdiyana W., Extraction of Essential Oil from Cinnamon (Cinnamomum zeylanicum), Oriental Journal of Chemistry, 30(1):37-47 (2014).

[24] Salgın U., Extraction of Jojoba Seed Oil Using Supercritical CO²⁺ Ethanol Mixture in Green and High-Tech Separation Process, The Journal of Supercritical Fluids, 39(3): 330-337 (2007).

[25] Anitescu G., Tavlarides L., Supercritical Extraction of Contaminants from Soils and Sediments, The Journal of Supercritical Fluids, 38(2):167-180 (2006).

[26] Mukhopadhyay M., "Natural Extracts Using Supercritical Carbon Dioxide", CRC press. (2000).

[27] Eckert C.A., Supercritical Fluids as Solvents for Chemical and Materials Processing, Nature., 383: 313-318 (1996).

[28] Şanal İ., Bayraktar E., Mehmetoğlu Ü., Çalımlı A., Determination of Optimum Conditions for SC-(CO₂ + ethanol) Extraction of β-Carotene from Apricot Pomace Using Response Surface Methodology, The Journal of Supercritical Fluids, 34(3):8-331 (2005).

[29] Sarker M.Z.I., Selamat J., Habib A.S.M.A., Ferdosh S., Akanda M.J.H., Jaffri J.M., Optimization of Supercritical CO₂ Extraction of Fish Oil from Viscera of African Catfish (Clarias gariepinus), International Journal of Molecular Sciences, 13(9):11312-11322 (2012).

[30] Ara K.M., Jowkarderis M., Raofie F., Optimization of Supercritical Fluid Extraction of Essential Oils and Fatty Acids from Flixweed (Descurainia Sophia L.) Seed Using Response Surface Methodology and Central Composite Design, Journal of Food Science and Technology, 52(7):4450-4458 (2015).

[31] Lu T., Gaspar F., Marriott R., Mellor S., Watkinson C., Al-Duri B., et al., Extraction of Borage Seed oil by Compressed CO₂: Effect of Extraction Parameters and Modelling, The Journal of Supercritical Fluids, 41(1):68-73 (2007).