Synthesis of Benzo[b][1,4]oxazine-2-amines via the Multicomponent Reaction between Benzyl Alcohol, 2-aminophenol, and Isocyanide by Using Urea Hydrogen Peroxide in the Presence of Magnesium Bromide Catalyst

Document Type : Research Article


Department of Chemistry, Razi University, Kermanshah, I.R. IRAN


A three-component reaction between the derivatives of benzyl alcohol, 2-aminophenol, and isocyanide for preparation Benzo[b][1,4]oxazine-2-amine derivatives has been reported. In this reaction, benzaldehyde derivatives were obtained as in situ from benzyl alcohol under oxidation by in urea hydrogen peroxide and magnesium bromide catalyst. This reaction was preferred in High efficiency and easy separation products of the reaction conditions. 


Main Subjects

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