Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, I.R. IRAN
Abstract
Solid lipid nanoparticles form colloidal drug carrier systems, which are alternative carrier systems to traditional colloidal carriers, such as emulsions, liposomes, and, polymeric micro and nanoparticles. Solid lipid nanoparticles are typically spherical with an average diameter between 1 and 1000 nm, which are dispersed in the water or the aqueous surfactant. Various techniques are used to synthesize these nanoparticles. A variety of methods can be applied to loading different drugs, ranging from hydrophobic to hydrophilic, into lipid nanoparticles. These nanoparticles are used as suitable carriers for drug delivery. However, the physicochemical stability of lipid nanoparticles is one of the major goals for long-term use in the pharmaceutical industry. In this study, the investigations in the presence and absence of cryoprotectants have been considered for the stabilization of the lipid nanoparticles. Studies have shown that 1% concentration of sucrose results in the stability of nanoparticles size after nine months. Also, laboratory release studies revealed no change in release profiles of stabilized lipid nanoparticles.
Pakravan, P. (2019). Synthesis of Solid Lipid Nanoparticles and Cryoprotectant Effect on Their Size Stabilization. Nashrieh Shimi va Mohandesi Shimi Iran, 38(2), 11-18.
MLA
Parvaneh Pakravan. "Synthesis of Solid Lipid Nanoparticles and Cryoprotectant Effect on Their Size Stabilization". Nashrieh Shimi va Mohandesi Shimi Iran, 38, 2, 2019, 11-18.
HARVARD
Pakravan, P. (2019). 'Synthesis of Solid Lipid Nanoparticles and Cryoprotectant Effect on Their Size Stabilization', Nashrieh Shimi va Mohandesi Shimi Iran, 38(2), pp. 11-18.
VANCOUVER
Pakravan, P. Synthesis of Solid Lipid Nanoparticles and Cryoprotectant Effect on Their Size Stabilization. Nashrieh Shimi va Mohandesi Shimi Iran, 2019; 38(2): 11-18.