Preparation and Characterization of a New Silver/ Starch – Poly(diphenylsulfonyl phthalate) Nanocomposite and Study of Its Drug Releasing

Document Type : Research Article

Authors

1 Department of Chemistry, Payame Noor University (PNU), Tehran, I. R. IRAN

2 Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, I.R. IRAN

Abstract

Today, polymer-based nanocomposites are used in medicine and drug delivery  Non-toxic and environmentally friendly nanocomposites are very important. In this study, new polyester-based nanocomposites were prepared using silver nanoparticles, starch, and poly(diphenylsulfonyl phthalate). The structure and morphology of the new nanocomposite were investigated using FT-IR, XRD, DLS, and FE- SEM. Swelling and drug release of the new nanocomposite were determined based on different amounts of silver nanoparticles. A polymeric alloy of starch and poly(diphenylsulfonyl phthalate) had the highest swelling. Drug loading and release in nanocomposites decreased approximately with the increasing amount of silver nanoparticles.

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References

[1] Chomoucka J., Drbohlavova J., Huska D., Adam V., Kizek R., Hubalek J., Magnetic Nanoparticles and Targeted Drug Delivering, Pharm. Res., 62(2): 144-149 (2010).
[2] Silva A.R., Zaniquelli M.E.D., Baratti, M.O., Jorge, R.A., Drug Release from Microspheres and Nanospheres of Poly(lactide-co-glycolide) without Sphere Separation from the Release Medium, J. Braz. Chem. Soc., 21: 214-225 (2010).
[3] Choi S.H., Kim D.H., Raghu A.V., Reddy K.R., Lee H.-I., Yoon K.S., Jeong H.M., Kim B.K., Properties of Graphene/Waterborne Polyurethane Nanocomposites Cast from Colloidal Dispersion Mixtures, Journal of Macromolecular Science Part B., 51: 197-207 (2012).
[4] Han S.J., Lee H.-I., Jeong H.M., Kim B.K., Raghu A.V., Reddy K.R., Graphene Modified Lipophilically by Stearic Acid and Its Composite with Low Density Polyethylene, Journal of  Macromolecular  Science Part B, 53(7): 1193-1204 (2014).
[5] Hassan M., Reddy K.R., Haque E., Minett A.I., Gomes V.G., High-Yield Aqueous Phase Exfoliation of Graphene for Facile Nanocomposite Synthesis via Emulsion Polymerization, J. Colloid Interface Sci., 410: 43-51 (2013).
[6] Hassan M., Reddy K.R., Haque E., Faisal S.N., Ghasemi S., Minett A.I., Gomes V.G., Hierarchical Assembly of Graphene/Polyaniline Nanostructures to Synthesize Free-Standing Supercapacitor Electrode, Compos. Sci. Technol., 98: 1-8 (2014).
[7] Lee Y.R., Kim, S.C., Lee H.-I., Jeong H.M., Raghu A.V., Reddy K.R., Kim B.K., Graphite Oxides as Effective Fire Retardants of Epoxy Resin,  Macromol. Res., 19(1): 66-71 (2011).
[8] Morris E.A., Weisenberger M.C., Bradley S.B., Abdallah M.G., Mecham S.J., Pisipati P., McGrath J.E., Synthesis, Spinning, and Properties of Very High Molecular Weight Poly(Acrylonitrile-Co-Methyl Acrylate) for High Performance Precursors for Carbon Fiber, Polym., 55: 6471-6482 (2014).
[9] Reddy K.R., Hassan M., Gomes V.G., Hybrid Nanostructures Based on Titanium Dioxide for Enhanced Photocatalysis, Appl. Catal. A. General., 489: 1-16 (2015).
[10] Mohan Y.M., Vimala K., Thomas V., Varaprasad K., Sreedhar B., Bajpai S.K., Raju K.M.J., Controlling of Silver Nanoparticles Structure by Hydrogel Networks,  J. Colloid Interface Sci., 342(1): 73-82 (2010).
[11] نوبخت اصل، فاطمه؛ کردتبار، مهران، سنتز و شناسایی هیدروژل های ابر جاذب نانوکامپوزیت مغناطیسی آهن بر پایه صمغ زانتان اصلاح شده با استفاده از اکریلیک اسید، نشریه شیمی و مهندسی شیمی ایران، (4)35: 33 تا 38 (1395). 
[12] Bardajee G.R. Hooshyar Z., Kabiri F., Preparation and Investigation on Swelling and Drug Delivery Properties of a Novel Silver/Salep-g-Poly (Acrylic Acid) Nanocomposite Hydrogel, Bull. Korean Chem. Soc., 33(8): 2635-2641 (2012).  
[13] معادی، تارا؛ قهرمان زاده، رامین؛ یوسفی، مریم؛ محمدی، فرشته، تهیه نانوذره های نقره توسط عصاره چهار گونه گیاهی و بررسی ویژگی های ضد میکروبی آن، نشریه شیمی و مهندسی شیمی ایران، (4)33: 1 تا 9 (1393).
[14] Javidi J., Esmaeilpour M., Synthesis of Fe3O4@silica/poly(N-isopropylacrylamide) as a Novel Thermo-Responsive System for Controlled Release of H3PMo12O40 Nano Drug in AC Magnetic Field, Colloids Surf., B. Biointerfaces., 102: 265-272 (2013).
[15] Uskoković-Marković S., Milenković  M., Topić A., Kotur-Stevuljević J., Stefanović A., Antić-Stanković J., Protective Effects of Tungstophosphoric Acid and Sodium Tungstate on Chemically Induced Liver Necrosis in Wistar Rats, Journal of Pharm Pharmaceutical Sciences, 10(3): 340-349  (2007)
[16] Hamidian H., Tavakoli T., Preparation of a New Fe3O4/Starch-G-Polyester Nanocomposite Hydrogel and a Study on Swelling and Drug Delivery Properties, Carbohydr. Polym., 144: 140-148 (2016).

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